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120444-71-5

Deramciclane is a non-benzodiazepine anxiolytic and antipsychotic drug that was once under investigation for its potential medical use in treating schizophrenia and Alzheimer's disease. It is a member of the ergoline family and functions as a serotonin antagonist and reuptake inhibitor. Additionally, it has an impact on dopamine and adrenergic receptor systems, which contribute to its psychopharmacological profile. Although trials indicated its potential for treating generalized anxiety disorders, its clinical development was discontinued due to insufficient efficacy, and it is no longer actively researched or marketed as a medicinal product.

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  • 120444-71-5 Structure

  • Basic information

    1. Product Name: DERAMCICLANE
    2. Synonyms: DERAMCICLANE;N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine
    3. CAS NO:120444-71-5
    4. Molecular Formula: C20H31NO
    5. Molecular Weight: 301.471
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 120444-71-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 375.2°Cat760mmHg
    3. Flash Point: 110.6°C
    4. Appearance: /
    5. Density: 1.01g/cm3
    6. Vapor Pressure: 7.93E-06mmHg at 25°C
    7. Refractive Index: 1.541
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain)
    11. CAS DataBase Reference: DERAMCICLANE(CAS DataBase Reference)
    12. NIST Chemistry Reference: DERAMCICLANE(120444-71-5)
    13. EPA Substance Registry System: DERAMCICLANE(120444-71-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 120444-71-5(Hazardous Substances Data)

120444-71-5 Usage

Uses

Used in Pharmaceutical Research:
Deramciclane was investigated as a potential anxiolytic and antipsychotic agent for the treatment of schizophrenia and Alzheimer's disease. It was used as a research compound for understanding its effects on the serotonin, dopamine, and adrenergic receptor systems, which are implicated in these conditions.
Used in Clinical Trials:
In the past, Deramciclane was used as a test drug in clinical trials to assess its efficacy in treating generalized anxiety disorders. The trials aimed to evaluate its potential as a non-benzodiazepine anxiolytic and antipsychotic medication, but the results led to the discontinuation of its clinical development due to insufficient efficacy.
Note: Since Deramciclane's clinical development was halted and it is no longer actively researched or sold as a medicinal product, there are no current applications in different industries. The uses mentioned above are historical and pertain to its past research and development stages.

Check Digit Verification of cas no

The CAS Registry Mumber 120444-71-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,4,4 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 120444-71:
(8*1)+(7*2)+(6*0)+(5*4)+(4*4)+(3*4)+(2*7)+(1*1)=85
85 % 10 = 5
So 120444-71-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H31NO/c1-18(2)17-11-12-19(18,3)20(15-17,22-14-13-21(4)5)16-9-7-6-8-10-16/h6-10,17H,11-15H2,1-5H3/t17-,19-,20+/m1/s1

120444-71-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine

1.2 Other means of identification

Product number -
Other names deramciclane,(1R,2S,4R)-isomer

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120444-71-5 SDS

120444-71-5Relevant articles and documents

High purity (1R,2S,4R)-(-)-2-[(2′-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts thereof

-

Example 2, (2010/11/29)

The invention relates to high purity (1R,2S,4R)-(?)-2-[(2′-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2% of (1R,3S,4R)-3-[(2′-{N,N

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