1204472-91-2Relevant academic research and scientific papers
Highly regio- And enantioselective synthesis of N-substituted 2-pyridones: Iridium-catalyzed intermolecular asymmetric allylic
Zhang, Xiao,Yang, Ze-Peng,Huang, Lin,You, Shu-Li
, p. 1873 - 1876 (2015)
The first iridium-catalyzed intermolecular asymmetric allylic amination reaction with 2-hydroxypyridines has been developed, thus providing a highly efficient synthesis of enantioenriched N-substituted 2-pyridone derivatives from readily available starting materials. This protocol features a good tolerance of functional groups in both the allylic carbonates and 2-hydroxypyridines, thereby delivering multifunctionalized heterocyclic products with up to 98% yield and 99% ee.
Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of 2-allyloxypyridines and related heterocycles
Rodrigues, Alessandro,Lee, Ernest E.,Batey, Robert A.
supporting information; experimental part, p. 260 - 263 (2010/03/24)
(Figure Presented) Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of (E)- and (Z)-allyloxy substituted N-heterocycles generates W-allyl N-heterocyclic amides In good yields and high enantioselectivities (up to 96% ee). The chiral palladacycle COP-Cl (5 mol %) Is used as a catalyst with silver(l) trifluoroacetate (10 mol %) at 35-45 °C. Examples of heterocycles synthesized include 2-pyridones, quinolin-2(1H)ones, and isoquinolin-1(2H)-ones.
