561024-13-3Relevant academic research and scientific papers
Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of 2-allyloxypyridines and related heterocycles
Rodrigues, Alessandro,Lee, Ernest E.,Batey, Robert A.
supporting information; experimental part, p. 260 - 263 (2010/03/24)
(Figure Presented) Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of (E)- and (Z)-allyloxy substituted N-heterocycles generates W-allyl N-heterocyclic amides In good yields and high enantioselectivities (up to 96% ee). The chiral palladacycle COP-Cl (5 mol %) Is used as a catalyst with silver(l) trifluoroacetate (10 mol %) at 35-45 °C. Examples of heterocycles synthesized include 2-pyridones, quinolin-2(1H)ones, and isoquinolin-1(2H)-ones.
