120450-33-1

Upstream product

• 7471-33-2 o-(4-isopropyl benzoyl) benzoic acid 
• 98-82-8 Isopropylbenzene 
• 85-44-9 phthalic anhydride 

Downstream Products

• 257877-30-8 2-{2-[hydroxyimino-(4-isopropyl-phenyl)-methyl]-phenyl}-benzo[d][1,3]oxazin-4-one 
• 102990-38-5 4-(4-isopropylphenyl)phthalazin-1(2H)-one 
• 257877-36-4 4-(p-isopropylphenyl)-2,3-1H-benzoxazine-1-thione 

Relevant academic research and scientific papers

Phthalazines and phthalazine hybrids as antimicrobial agents: Synthesis and biological evaluation

Phthalazine and phthalazinone derivatives are important owing to their significant biological activities and pharmacological properties. Herein, a benzoic acid derivative (2), a benzoxazin-1-one derivative (3), and an oxophthalazin-2(1H)-yl)acetohydrazide (13) are utilized as precursors to construct a novel series of phthalazinones bearing various valuable functional groups in excellent yields via several simple and promising approaches. Finally, the antimicrobial activity of the newly synthesized phthalazines is screened against different microbial strains; namely, Gram-negative and Gram-positive bacteria utilizing Amoxicillin as a standard drug.

Copper-catalysed rearrangement of 4-substituted-2,3-1H-benzoxazine-1-thiones

4-Substituted-2,3-1H-benzoxazine-1-thiones were prepared by the treatment of the corresponding benzoxazine-1-ones with P2S5. The thermal rearrangement of 4-substituted-2,3-1H-benzoxazine-1-thiones, catalysed by metallic copper, yield

Synthesis of Some 4-Substituted 1H-2,3-Benzoxazin-1-ones

The title compounds have been prepared by treating the corresponding o-aroylbenzoic acids with hydroxylamine hydrochloride and sodium acetate in ethanol, and their structures established by elemental analyses and spectral data.The mechanism suggested for