1204501-06-3Relevant academic research and scientific papers
Preparation of tethered aldehyde ynoates and ynones by ring fragmentation of cyclic γ-oxy-β-hydroxy-α-diazo carbonyls
Bayir, Ali,Draghici, Cristian,Brewer, Matthias
supporting information; experimental part, p. 296 - 302 (2010/03/30)
(Chemical Equation Presented) Cyclic γ-oxy-β-hydroxy-α- diazo carbonyls undergo Lewis acid induced ring fragmentation to provide either ynoates or ynones tethered to an aldehyde, ketone, or ester. The fragmentation precursors are convenient to prepare by adding lithiated α-diazo carbonyls to α-oxy ketones. The fragmentation appears general and provides a variety of functional group-rich products in good to excellent yield.
