74173-08-3

Basic information

• Product Name: 2-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&
• Synonyms: 2-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&;2-TERT-BUTYLDIMETHYLSILYLOXYCYCLOHEXANO&;2-(tert-Butyldimethylsilyloxy)cyclohexanone 97%;2-[Tert-Butyl(Dimethyl)Silyl]Oxycyclohexan-1-One;2-[t-Butyl(Dimethyl)Silyl]Oxy Cyclohexan-1-One
• CAS NO: 74173-08-3
• Molecular Formula: C₁₂H₂₄O₂Si
• Molecular Weight: 228.41
• Product Categories: C11 to C12;Carbonyl Compounds;Ketones
• Mol File: 74173-08-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 55-59 °C0.05 mm Hg(lit.)
• Flash Point: 200 °F
• Appearance: /
• Density: 1.969 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0112mmHg at 25°C
• Refractive Index: n20/D 1.454(lit.)
• CAS DataBase Reference: 2-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&(74173-08-3)
• EPA Substance Registry System: 2-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&(74173-08-3)

Safety Data

• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• TSCA: No
• Hazardous Substances Data: 74173-08-3(Hazardous Substances Data)

Usage

General Description

2-(tert-butyldimethylsilyloxy)cyclohexa-1,3-diene is a chemical compound with the molecular formula C13H26OSi. It is a derivative of cyclohexa-1,3-diene, with a tert-butyldimethylsilyloxy functional group attached to the cyclohexene ring. 2-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA& is commonly used in organic synthesis as a protecting group for alcohols, amines, and carboxylic acids. The tert-butyldimethylsilyloxy group can be easily removed under mild conditions, making it a useful tool for controlling reactions in organic chemistry. 2-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA& is also used as a precursor in the synthesis of various pharmaceuticals and other organic compounds.

InChI:InChI=1/C12H24O2Si/c1-12(2,3)15(4,5)14-11-9-7-6-8-10(11)13/h11H,6-9H2,1-5H3

Upstream product

• 62791-22-4 tert-butyl(cyclohex-1-en-1-yloxy)dimethylsilane 
• 77086-38-5 ketene t-butyldimethylsilyl methyl acetal 
• 55705-17-4 α-(phenylsulfinyl)cyclohexanone 
• 362480-54-4 3-hydroxy-2-oxo-cyclohexanecarboxylic acid methyl ester 
• 233262-34-5 2,2-dimethoxy-cyclohexanecarboxylic acid methyl ester 
• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 
• 25662-41-3 Methyl-2-methoxy-2-cyclohexen-1-carboxylat 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 533-60-8 cyclohexanone-2-ol 
• 362480-55-5 3-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexanecarboxylic acid methyl ester 

Downstream Products

• 134559-21-0 C₁₄H₂₇NO₃Si 
• 1350520-18-1 3-(1-((tert-butyldimethylsilyl)oxy)-2-oxocyclohexyl)propanoic acid 
• 1350520-15-8 benzyl 3-(1-((tert-butyldimethylsilyl)oxy)-2-oxocyclohexyl)propanoate 
• 1350520-21-6 2-(tert-butyldimethylsilyloxy)-2-(4-diazo-3-oxobutyl)cyclohexanone 
• 1353042-75-7 6-(tert-butyldimethylsilyloxy)cyclohex-1-en-1-yl nonaflate 
• 1204501-09-6 tert-butyl (3S)-1-(2-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-1-diazo-4-methyl-2-oxopentan-3-ylcarbamate 
• 1204501-05-2 benzyl (3S)-1-(2-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-1-diazo-4-methyl-2-oxopentan-3-ylcarbamate 
• 1204501-06-3 benzyl (2S)-2-(2-(2-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2-diazoacetyl) pyrrolidine-1-carboxylate 
• 1204501-07-4 benzyl (2S)-4-(2-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-4-diazo-3-oxo-1-phenylbutan-2-ylcarbamate 

Relevant articles and documents

A new non-azole inhibitor of ABA 8′-hydroxylase: Effect of the hydroxyl group substituted for geminal methyl groups in the six-membered ring

We designed and synthesized AHI4 that has an axial hydroxyl group instead of geminal methyl groups at C-6′ of AHI1, previously reported as a lead compound for the development of non-azole inhibitors of ABA 8′-hydroxylase. (+)-AHI4 competitively inhibited

Preparation of tethered aldehyde ynoates and ynones by ring fragmentation of cyclic γ-oxy-β-hydroxy-α-diazo carbonyls

(Chemical Equation Presented) Cyclic γ-oxy-β-hydroxy-α- diazo carbonyls undergo Lewis acid induced ring fragmentation to provide either ynoates or ynones tethered to an aldehyde, ketone, or ester. The fragmentation precursors are convenient to prepare by adding lithiated α-diazo carbonyls to α-oxy ketones. The fragmentation appears general and provides a variety of functional group-rich products in good to excellent yield.

Simple and efficient MW-assisted cleavage of acetals and ketals in pure water

Simple and efficient MW-assisted cleavage of acetal and ketal is proposed in deionized water and in a very short time.