1204524-75-3Relevant academic research and scientific papers
A Facile One-Step Synthesis of 2-Arylindazoles via Reductive Cyclization of N-(2-nitroarylidene)amines
Lin, Wei,Hu, Minghua,Feng, Xian,Cao, Chengpao,Huang, Zhibin,Shi, Daqing
, p. 1170 - 1174 (2015)
A mild and efficient synthesis of 2-arylindazole derivatives via the reductive cyclization of nitro-aryl substrates mediated by a low-valent titanium reagent (TiCl4/Sm/Et3N) has been developed. The attractive features of the current method include an N-N bond formation and the selective reduction of the =C-N bond and nitro group, both of which were easily achieved in one-pot by controlling the pH of the reaction mixture.
Oriented synthesis and in vitro anticancer activity of biquinazoline-2,2'- diones
Dou, Guolan,Shi, Daqing,Li, Yonghai
scheme or table, p. 195 - 199 (2010/11/02)
The synthesis of a series of biquinazoline-2,2'-diones starting from o-nitrobenzaldehydes, anilines, and triphosgene is presented. This general approach features a novel and easy way for access to the target products. The mechanistic course of the reaction suggests the involvement of reduction, coupling, and cyclization by one-pot. These compounds were also investigated in vitro for anticancer activity, and some were found to have good anticancer activity.
