1204530-92-6Relevant articles and documents
Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction
Bach, Anders,Chi, Celestine N.,Pang, Gar F.,Olsen, Lars,Kristensen, Anders S.,Jemth, Per,Stromgaard, Kristian
, p. 9685 - 9689 (2009)
On the double: Dimerization of monomeric peptide ligands towards the PDZ domains of the protein PSD-95 (postsynaptic density 95) leads to potent inhibitors of protein-protein interactions with stability in blood plasma. Optimization of the length of the polyethylene glycol linker results in unprecedented affinity for inhibitors of the PDZ1-2 domain (see picture).
