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Usage

Uses

Used in Pharmaceutical Industry:
alpha, oMega-Dipropionic acid hexaethylene glycol is used as a PEG linker for improving the solubility and stability of drug molecules. The hydrophilic PEG spacer enhances the solubility of hydrophobic drugs in aqueous media, while the terminal carboxylic acids allow for the formation of stable amide bonds with primary amine groups on drug molecules.
Used in Bioconjugation:
alpha, oMega-Dipropionic acid hexaethylene glycol is used as a bioconjugation agent for attaching various biomolecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The terminal carboxylic acids can react with primary amine groups on the target biomolecules, forming stable amide bonds and facilitating the attachment process.
Used in Drug Delivery Systems:
alpha, oMega-Dipropionic acid hexaethylene glycol is used as a component in drug delivery systems to improve the solubility, stability, and targeted delivery of therapeutic agents. The hydrophilic PEG spacer and terminal carboxylic acids can be utilized to attach drug molecules or other functional groups, enhancing the overall performance of the drug delivery system.

Upstream product

• 638-56-2 1,11-dichloro-3,6,9-trioxaundecane 
• 2615-15-8 pentaethylene glycol 
• 41263-80-3 4,7,10,13,16,19,22-heptaoxapentacosanedinitrile 

Downstream Products

• 929087-94-5 3-[2-(2-{2-[2-(2-{2-[2-(4-{2-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-[1,3]dioxolan-2-yl]-ethyl}-phenylcarbamoyl)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-propionic acid 
• 1204530-92-6 (IESDV)₂PEG₆ 

Relevant academic research and scientific papers

Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use

Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.

Intramolecular End-to-End Reactions of Photoactive Terminal Groups Linked by Poly(oxyethylene) Chains

The triplet-sensitized photochemical reaction using a series of poly(oxyethylene) chains with a pair of photoactive terminal groups, dibenzazepine (DBA) chromophores (DBA-COCH2CH2(OCH2CH2)nOCH2CH2CO-DBA, n=0-10) was examined.The photoirradiation of bichromophoric compounds caused either intra- or intermolecular reactions.These reactions were kinetically analyzed by two different methods: the measurement of deactivation processes of the reaction intermediates (excited triplet state of DBA) by nanosecond laser photolysis and the quantitative analysis of the reaction products by GPC.The intramolecular deactivation rate constant, kintra, showed a remarkable chain-length dependence; the maximum kintra value appeared at n=5 and it was found to be 5.9X104 s-1.On the other hand, the intramolecular cyclization rate also depends on the chain length; the maximum quantum yield, φintrad, was given at n=7 (φintrad=0.51).The chain length for the maximum cyclization yield shifted slightly to the longer region than that for the maximum kintra value due to the restriction of the terminal structure (anti-configuration).The results obtained for this reaction system are compared with those obtained for the previously reported polymethylene system and the effect of chain flexibility on the intramolecular ring-closure reaction is discussed.