1204575-07-4Relevant academic research and scientific papers
Radiosynthesis of a carbon-11-labeled AMPAR allosteric modulator as a new PET radioligand candidate for imaging of Alzheimer's disease
Miao, Caihong,Dong, Fugui,Jia, Limeng,Li, Wei,Wang, Min,Zheng, Qi-Huang,Xu, Zhidong
, p. 1177 - 1181 (2019)
To develop PET tracers for imaging of Alzheimer's disease, a new carbon-11-labeled AMPAR allosteric modulator 4-cyclopropyl-7-(3-[11C]methoxyphenoxy)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide ([11C]8) has been synthesized
Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2
Krintel, Christian,Francotte, Pierre,Pickering, Darryl S.,Juknaite, Lina,P?hlsgaard, Jacob,Olsen, Lars,Frydenvang, Karla,Goffin, Eric,Pirotte, Bernard,Kastrup, Jette S.
, p. 2397 - 2406 (2016)
The 1,2,4-benzothiadiazine 1,1-dioxide type of positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g., Alzheimer's disease. The modulators bind in a cleft
Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them
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Page/Page column 23, (2010/02/17)
Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group,R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.
