1204589-80-9

Usage

Uses

Used in Recreational Substances:
(S)-1-phenyl-3-(piperidin-1-yl)propan-2-amine is used as a recreational substance for its euphoric and empathogenic effects, which contribute to its popularity among users seeking to experience altered states of consciousness and increased sensory perception.
Used in Research and Development:
(S)-PPPA may also be utilized in the research and development of new pharmaceuticals and therapies, particularly in the fields of neurology and psychiatry, due to its psychoactive properties and effects on the central nervous system.

Upstream product

• 102292-89-7 (2S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one 
• 126301-19-7 (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 63-91-2 L-phenylalanine 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 120125-43-1 (S)-tert-butyl (1-oxo-3-phenyl-1-(piperidin-1-yl)propan-2-yl)carbamate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 110-89-4 piperidine 

Downstream Products

• 1204589-74-1 (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(1-phenyl-3-(piperidin-1-yl)propan-2-yl)thiourea 
• 1454257-29-4 3-((S)-3-phenyl-1-(piperidin-1-yl)propan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione 

Relevant academic research and scientific papers

A new type of L-Tertiary leucine-derived ligand: Synthesis and application in Cu(II)-catalyzed asymmetric Henry reactions

A new series of Schiff bases derived from amino acids were developed as chiral ligands for Cu(II)-catalyzed asymmetric Henry reactions. The optimum ligand 7d exhibited outstanding catalytic efficiency in the Cu(II)-catalyzed asymmetric Henry additions of four nitroalkanes to different kinds of aldehydes to produce 76 desired adducts in high yields (up to 96%) with excellent enantioselectivities, up to 99% enantiomeric excess (ee).

Synthesis and antimalarial activity of new 4-aminoquinolines active against drug resistant strains

In the present study we have synthesized a new class of 4-aminoquinoline derivatives via replacement of the diethylamine functionality of chloroquine (CQ) with acyclic and/or cyclic amine groups containing basic tertiary terminal nitrogen and bioevaluated them for antimalarial activity against Plasmodium falciparum in vitro (CQ-sensitive strain-3D7 & CQ-resistant strain-K1) and Plasmodium yoelii in vivo (N-67 strain). Among the series, thirteen compounds showed superior antimalarial activity against K1 strain as compared to CQ. In addition, all these analogs showed 100% suppression of parasitaemia on day 4 in the in vivo mouse model against N-67 strain when administered orally. Further, biophysical studies suggest that these compounds act on the heme polymerization target.

Chiral primary amine catalyzed asymmetric direct cross-aldol reaction of acetaldehyde

The first primary aminocatalytic direct cross-aldol reaction of acetaldehyde is presented. Among the various vicinal diamines screened, the L-tert-leucine derivative 1c in conjunction with (H4SiW 12O40)0.25 was identified as the optimal catalyst; good catalytic activity (up to 99% yield in 4 h), and high enantioselectivities (up to 92% ee) were achieved for a range of donors, including aromatic aldehydes and isatin derivatives. Aqueous acetaldehyde solution and paraldehyde can be conveniently applied in this system.

Highly enantio- and diastereoselective synthesis of α- trifluoromethyldihydropyrans using a novel bifunctional piperazine-thiourea catalyst

The first enantioselective Michael addition of α-cyanoketones to α,β-unsaturated trifluoromethyl ketones using a novel piperazine-thiourea catalyst was described. The resulting α- trifluoromethyldihydropyrans were obtained in high yields and with up to 95