1204608-06-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-3-(2-Chloro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester is used as a key intermediate for the synthesis of various drugs. Its role in the pharmaceutical industry is to facilitate the production of drugs that target specific medical conditions, contributing to the development of novel therapeutic options.
Used in Drug Synthesis:
In the field of drug synthesis, (S)-3-(2-Chloro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester is utilized as a building block for creating pharmaceutical compounds. Its unique chemical structure allows for the formation of new drugs with potential therapeutic applications in treating specific medical conditions.
Used in Medical Research:
(S)-3-(2-Chloro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester is also used in medical research to explore its potential therapeutic applications. Researchers investigate its properties and interactions with biological systems to understand its effectiveness in treating certain medical conditions and to identify new areas of application within the healthcare sector.

Upstream product

• 79-04-9 chloroacetyl chloride 
• 625471-18-3 tert-butyl (3S)-3-aminopiperidine-1-carboxylate 

Relevant academic research and scientific papers

An Improved Convergent Synthesis of AZD7762: A One-Pot Construction of a Highly Substituted Thiophene at the Multikilogram Scale

A multikilogram synthesis of AZD7762 has been achieved using a highly convergent route employing two efficient telescoped sequences to generate the key intermediates. Aminothiophene 11 is formed in a four-step, one-pot addition-elimination-cyclization sequence from cinnamonitrile 9, constructing the trisubstituted thiophene ring with the desired API substitution pattern in place. Cinnamonitrile 9 is derived by elaboration of 3-fluoroacetophenone. Generation of the urea function, followed by deprotection, affords AZD7762 in 49% yield over 5 isolated stages from chiral piperidine 5, a 5-fold increase in yield versus the first generation route, reducing the starting material burden and eliminating the previous requirement for metal-mediated couplings and chromatography.

5 -AMIDOTHIAZOLE DERIVATIVES AND THEIR USE AS CHECKPOINT KINASE INHIBITORS

The present invention pertains to certain thiazole carboxylic acid amide compounds which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function and/or Checkpoint Kinase 2 (CHK2) kinase function, to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHKl kinase function and/or CHK2 kinase function, and in the treatment of diseases and conditions that are mediated by CHKl and/or CHK2, that are ameliorated by the inhibition of CHKl kinase function and/or CHK2 kinase function, such as cancer, optionally in combination with another agent, for example, (a) a DNA topoisomerase I or Il inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation.

METHODS OF PREPARING SUBSTITUTED HETEROCYCLES

The present disclosure relates to methods of preparing substituted thiophenes, which are useful for the treatement and prevention of cancers. Also disclosed are substituted thiophenes made by the methods disclosed herein.