1204614-75-4Relevant academic research and scientific papers
Dynamic structural transformation of resveratrol-modified stearate liposomes led to a spontaneous drug release system
Chen, Li-Cho,Lin, Shih-Shan,Li, Cun-Zhao,Hsu, Hsiu-Fu,Weng, Yu-Jong,Cheng, Chien-Chung
, p. 1099 - 1102 (2013)
A mono-substituted resveratrol derivative, resveratrol-modified stearate (RMS), was synthesized by selectively coupling of stearic acid to the monohroxyphenyl of resveratrol in order to enhance both the stability and bioavailability of resveratrol. The RM
Lipophilization of resveratrol and effects on antioxidant activities
Oh, Won Young,Shahidi, Fereidoon
, p. 8617 - 8625 (2017)
Resveratrol (R), a polyphenol, was structurally modified via esterification with selected fatty acids to expand its potential application in lipophilic foods, drugs, and cosmetics. The esterification was carried out using 12 different fatty acids with varying chain lengths and degrees of unsaturation (C3:0-C22:6). Two monoesters, two diesters, and one triester were identified by high-performance liquid chromatography-mass spectrometry, and the monoesters (R-3-O-monodocosahexaenoate and R-4'-O-monodocosahexaenoate) were structurally confirmed by nuclear magnetic resonance. The lipophilicity of resveratrol and its alkyl esters was calculated using ALOGPS 2.1. Resveratrol exhibited greater antioxidant activity in both 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation scavenging assays. Resveratrol esters with long-chain fatty acids (C18:0 and C18:1) showed higher antioxidant activity in the DPPH radical scavenging assay, whereas short-chain fatty acid (C3:0, C4:0, and C6:0) showed higher antioxidant activity in the ABTS radical cation scavenging assay. The results may imply that resveratrol derivatives could be used in lipophilic media as health beneficial antioxidants.
