120522-49-8 Usage
Chemical structure
A quaternary ammonium compound with a piperidine ring, a hydroxyl group at the 2-position, a methyl group at the 1-position, and a phenyl group at the 4-position.
Composition
Consists of a piperidinium cation and an iodide anion.
Stereochemistry
The hydroxyl group is in the (2S) configuration.
Molecular weight
Approximately 444.45 g/mol (including the iodide anion).
Appearance
Likely a solid, though the exact physical state is not specified in the material.
Pharmacological use
Commonly used in research to study the effects of quaternary ammonium compounds on various biological processes.
Therapeutic potential
Explored for potential applications in the treatment of neurodegenerative diseases and neurological disorders.
Mechanism of action
The precise mechanism of action and biological effects are subject to ongoing investigation and study.
Solubility
The solubility properties are not specified in the material, but quaternary ammonium compounds are generally soluble in polar solvents like water.
Charge
The compound has a net positive charge due to the presence of the quaternary ammonium group.
Abbreviation
The abbreviation or common name for this compound is not provided in the material.
Hazards
The material does not provide information on the hazards or safety precautions associated with this compound. However, it is important to handle chemicals with caution and follow appropriate safety guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 120522-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,2 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 120522-49:
(8*1)+(7*2)+(6*0)+(5*5)+(4*2)+(3*2)+(2*4)+(1*9)=78
78 % 10 = 8
So 120522-49-8 is a valid CAS Registry Number.
120522-49-8Relevant articles and documents
Synthesis, in Vitro Acetylcholine-Storage-Blocking Activities, and Biological Properties of Derivatives and Analogues of trans-2-(4-Phenylpiperidino)cyclohexanol (Vesamicol)
Rogers, Gary A.,Parsons, Stanley M.,Anderson, D. C.,Nilsson, Lena M.,Bahr, Ben A.,et al.
, p. 1217 - 1230 (2007/10/02)
Eighty-four analogues and derivatives of the acetylcholine-storage-blocking drug trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol) were synthesized, and their potencies were evaluated with the acetylcholine active-transport assay utilizing purified synaptic vesicles from Torpedo electric organ.The parent drug exhibits enantioselectivity, with (-)-vesamicol being 25-fold more potent than (+)-vesamicol.The atomic structure and absolute configuration of (+)-vesamicol were determined by X-ray crystallography.The absolute configuration of (-)-vesamicol is 1R,2R.Structure-activity evidence indicates that (-)-vesamicol does not act as an acetylcholine analogue.Alterations to all three rings can have large effects on potency.Unexpectedly, analogues locking the alcohol and ammonium groups trans-diequatorial or trans-diaxial both exhibit good potency.A potent benzovesamicol family has been discovered that is suitable for facile elaboration of the sort useful in affinity labeling and affinity chromatography applications.A good correlation was found between potencies as assessed by the acetylcholine transport assay and LD50 values in mouse.
