120546-67-0 Usage
Uses
Used in Pharmaceutical Industry:
Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro(9CI) is used as an inhibitor for rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT). This application is significant because PNMT is an enzyme involved in the biosynthesis of catecholamines, which are neurotransmitters and hormones that play a crucial role in various physiological processes, including stress response, mood regulation, and alertness. By inhibiting PNMT, these compounds can potentially be used to modulate the levels of catecholamines in the body, which may have therapeutic implications for conditions related to catecholamine imbalances.
Check Digit Verification of cas no
The CAS Registry Mumber 120546-67-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,4 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 120546-67:
(8*1)+(7*2)+(6*0)+(5*5)+(4*4)+(3*6)+(2*6)+(1*7)=100
100 % 10 = 0
So 120546-67-0 is a valid CAS Registry Number.
120546-67-0Relevant academic research and scientific papers
Tetrahydrothiadiazoloisoquinolines: Synthesis and inhibition of phenylethanolamine-N-methyltransferase
Girard,Bondinell,Hillegass,Holden,Pendleton,Uzinskas
, p. 1566 - 1571 (2007/10/02)
A series of 7,8-fused heterocyclic tetrahydroisoquinolines were synthesized and tested as inhibitors of rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT). 6,7,8,9-Tetrahydro[1,2,3]thiadiazolo[5,4-h]isoquinoline 5 (SK and F 86607) was found to b
