1205548-00-0 Usage
Description
4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide, also known as 4'-Dimethylamino 7,8-Dihydroxyflavone, is a synthetic derivative of 7,8-Dihydroxyflavone. It is an orange-brown solid that has been found to promote neurogenesis and exhibit potent antidepressant effects. The 7,8-dihydroxy groups in its structure are crucial for its agonistic activity, and it has been shown to have higher TrkB agonistic activity than 7,8-Dihydroxyflavone (D452830).
Uses
Used in Pharmaceutical Industry:
4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide is used as a pharmaceutical agent for its antidepressant properties. It promotes neurogenesis and has a potent effect on alleviating depressive symptoms. The agonistic activity of this compound makes it a promising candidate for the development of new antidepressant medications.
Used in Research Applications:
In the field of neuroscience and pharmacology, 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide is used as a research tool to study the mechanisms underlying neurogenesis and the effects of TrkB agonists on neuronal development and function. Its higher TrkB agonistic activity compared to 7,8-Dihydroxyflavone makes it valuable for investigating the potential therapeutic applications of TrkB agonists in various neurological disorders.
Used in Drug Development:
4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide is utilized in the development of new drugs targeting neurological and psychiatric conditions. Its potent antidepressant effect and promotion of neurogenesis make it a valuable compound for creating novel therapeutics that could potentially offer better efficacy and fewer side effects than existing treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 1205548-00-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,5,5,4 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1205548-00:
(9*1)+(8*2)+(7*0)+(6*5)+(5*5)+(4*4)+(3*8)+(2*0)+(1*0)=120
120 % 10 = 0
So 1205548-00-0 is a valid CAS Registry Number.
1205548-00-0Relevant articles and documents
A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect
Liu, Xia,Chan, Chi-Bun,Jang, Sung-Wuk,Pradoldej, Sompol,Huang, Junjian,He, Kunyan,Phun, Lien H.,France, Stefan,Xiao, Ge,Jia, Yonghui,Luo, Hongbo R.,Ye, Keqiang
experimental part, p. 8274 - 8286 (2011/02/23)
7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. Our preliminary structural-activity relationship (SAR) study showed that the 7,8-dihydroxy groups are essential for the agonistic effect. To improv
