120568-90-3Relevant academic research and scientific papers
Alkyne Aminopalladation/Heck and Suzuki Cascades: An Approach to Tetrasubstituted Enamines
Geffers, Finn J.,Jones, Peter G.,Kurth, Florens R.,Werz, Daniel B.
supporting information, p. 14846 - 14850 (2021/10/19)
Alkyne aminopalladation reactions starting from tosylamides are reported. The emerging vinylic Pd species are converted either in an intramolecular Heck reaction with olefinic units or in an intermolecular Suzuki reaction by using boronic acids exhibiting broad functional group tolerance. Tetra(hetero)substituted tosylated enamines are obtained in a simple one-pot process.
THERAPEUTIC AGENTS, AND METHODS OF MAKING AND USING THE SAME
-
Page/Page column 116, (2010/11/27)
In part, the present invention is directed to antibacterial compounds
Diastereoselective intramolecular SmI2-H2O-amine mediated couplings
Dahlen, Anders,Petersson, Annika,Hilmersson, Goeran
, p. 2423 - 2426 (2007/10/03)
The effectiveness of SmI2-H2O-amine mixture for intramolecular couplings was discussed. Diastereoselectivities in the coupling of O-cyclohexanyliodophenol derivatives were provided into heterocycles. The amount of coupled product improved significantly as SmI2, the substrate and amine were premixed followed by a gradual addition of water.
The samarium grignard reaction. In situ formation and reactions of primary and secondary alkylsamarium(III) reagents
Curran, Dennis P.,Totleben, Michael J.
, p. 6050 - 6058 (2007/10/02)
This work shows that primary and secondary radicals are rapidly reduced in THF/HMPA to form primary- and secondary-alkylsamarium reagents. The primary- and secondary-radicals can be formed either by direct SmI2 reduction of primary- and secondary-halides or by a previous rapid radical cyclization. The samarium reagents have moderate stability in solution, and they react with a variety of typical electrophiles, including aldehydes and ketones. The work further shows that organosamarium intermediates can be involved in the traditional samarium Barbier reaction of aldehydes and ketones conducted in THF/HMPA. A new procedure called the "samarium Grignard" method is introduced, and it is suggested that this new procedure will have considerably more scope and generality than the samarium Barbier reaction.
