120573-16-2Relevant academic research and scientific papers
Newer Quinazolinone Derivatives as Anthelmintic Agents
Gupta, D. P.,Ahmad, S.,Kumar, Ashok,Shanker, K.
, p. 1060 - 1062 (2007/10/02)
Five types of quinazolinone derivatives have been synthesized. 3-Amino-2-methyl-4(3H)-quinazolinones (I) on treatment with chloroacetyl chloride give the 3-chloroacetamido derivatives (II) which react with secondary and primary amines to afford the corresponding 3-substituted acetamido derivatives (III and IV).The 3-amino-quinazolinones (I) also react with aryl and alkyl halides to afford the corresponding 3-aryl/alkyl-amino derivatives (V-VII).These compounds (III-VII) have been tested for their acetylcholinesterase inhibitory activity and anthelmintic activity against H. nana.
