89258-53-7Relevant academic research and scientific papers
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity
ElZahabi, Heba S.A.,Nafie, Mohamed S.,Osman, Dina,Elghazawy, Nehal H.,Soliman, Dalia H.,EL-Helby, Abdelghany Ali H.,Arafa, Reem K.
, (2021/06/15)
This work presents the design and synthesis of a series of new quinazolin-4-one derivatives, based on the established effectiveness of quinazoline-based small molecules as anticancer agents. Synthesized compounds were more potent against MCF-7 than A-549
Synthesis and bioactivities evaluation of novel vv-pyridylpyrazole derivatives with 1,2,3-triazole and quinazolin-4(3H)-one substructures
Wei, Wei,Zhu, Liangliang,Zhou, Yunyun,Li, Zhengming
, p. 1453 - 1462 (2018/08/29)
Two series of JV-pyridylpyrazole derivatives containing 1,2,3-triazole and quinazolin-4(3H)-one substructures were designed and synthesized. In total, 18 novel compounds were prepared, and all compounds were characterized by 1H NMR, 13C NMR and elemental
2-{2"-carbomyl-5"-[3′-amino-2′-methylmono/ dihalosubstituted quinazolin-4′(3'h)-onomethylene]- 1",3",4"-oxadiazol-2"-yl}-4,5-dihydroimidazolines as potential antihypertensive agents
Tyagi, Mirdula
, p. 713 - 721 (2015/01/16)
Twelve new 2- {2"-carbomyl - 5" - [3′-amino-2′ - methylmono / dihalosubstituted quinazolin- 4′ (3'H) - onomethylene] - 1",3",4" - oxadiazol-2"-yl} -4, 5- dihydroimidazolines were prepared and evaluated for their cardiovascular activity. The most active compound of this series is 2-{2"- carbomyl-5"-[3′-amino-2′-methyl-6-bromoquinazolin-4′(3'H)-onomethylene]-",3",4"-oxadiazol-2"- yl}-4,5-dihydroimidazolines i.e. compound VIc.
Synthesis and antimicrobial activities of some novel substituted 2-imidazolyl-N-(4-oxo-quinazolin-3(4H)-yl)-acetamides
Raghavendra, Nulgulmnalli Manjunathiah,Thampi, Parameshwaran,Gurubasavarajaswamy, Purvarga Mattada,Sriram, Dharmarajan
, p. 1615 - 1619 (2008/09/19)
Several substituted-quinazolin-3(4H)-ones 8-11ad were synthesized by condensation of 2-chloro-N-(4-oxosubstituted-quinazolin-3(4H)-yl)-acetamides with various substituted imidazoles through one pot reaction. Elemental analysis, IR, 1H-NMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolin-4-one derivatives were investigated for their antitubercular, antibacterial and antifungal activities. Some of the tested compounds showed good antitubercular activity. None of the synthesized compounds showed significant antibacterial and antifungal activity.
Synthesis, antitubercular and anticancer activities of substituted furyl-quinazolin-3(4H)-ones
Raghavendra, Nulgulmnalli M.,Thampi, Parameshwaran,Gurubasavarajaswamy, Purvarga M.,Sriram, Dharmarajan
, p. 635 - 641 (2008/12/21)
Some novel substituted-3-{[(1E)-(substituted-2-furyl)-methylene]amino} quinazolin-4(3H)-one (5, 6, 7) a-f were synthesized by a multi-step process. These synthesized compounds are characterized by various spectroscopic techniques and evaluated for their antitubercular and anticancer activities. Biological activity indicated that some of the title compounds are potent antitubercular and anticancer agents.
Synthesis and studies of the behaviour of 6,8-Dibromo-2-substituted 4H-3,1-benzoxazin-4-ones
Kassab, R. R.,El-Hashash, M. A.,Ahmad, I. GH.
, p. 487 - 500 (2007/10/03)
The title compounds 1a-c were prepared via reaction of 3,5-dibromo anthranilic acid with acetic anhydride, succinic anhydride and/or maleic anhydride. Reaction of 1a-c with hydrazine hydrate yielded the corresponding 3-amino quinazoline derivatives 2a-c. The reaction of 2a and/or 2b with aromatic aldehydes, namely 2,4-dichlorobenzaldehyde, 4-hydroxybenzaldehyde, and/or 4-methoxybenzaldehyde gave 3a-c, while the reaction of 1b with 2,4-dichlorobenzaldehyde in the presence of anhydrous ZnCl2 yielded 4. But when compound 2b was reacted with 2,4-dichlorobenzaldehyde in the presence of AcOH/Ac2O yielded 5, which was formed also when compound 4 was reacted with N2H4 in boiling ethanol. Treatment of compound 2c with maleic anhydride gave 6. On the other hand, 1a was reacted with 4-aminoacetophenone to give compound 7, and with NaN3 to give 9 and 10. The reaction of 1a with sulphadrugs afforded 11a-d. The structures of the new compounds were confirmed by analytical and different spectroscopic methods. The various compounds prepared are outlined in schemes 1 and 2. Significant antimicrobial activities were observed for some members of the series.
Synthesis of some new N-amidoaziridines
Hogale, M B,Chavan, P B
, p. 581 - 585 (2007/10/02)
Synthesis of some new N-amidoaziridines has been reported.Methyl/ethyl 1-aziridine-2-carboxylates (IIa-z) have been synthesized by lead tetraacetate oxidation of 3-amino-6,8-dibromo-2-methylquinazolin-4(3H)-o
6,8-Dibromo-2-methyl-1,3-4(3H)-quinazolinones
Ossmann, A. E.,El-Zahabi, M. M.,El-Hakim, A. E.,Osman, A. N.
, p. 113 - 114 (2007/10/02)
Hydrazinolysis of 6,8-dibromo-2-methyl-3,1-benzoxazin-4-(H)-one (1) afforded the 3-amino-6,8-dibromo-2-methyl-1,3,4(3H)-quinazoline (2a).Acylation of the latter with acetic anhydride and benzoyl chloride yielded the corresponding acetyl and benzoyl deriva
Synthesis of Quinazolinylpyrimidinediones and Their Anti-inflammatory Activity
Kumar, Atul,Singh, S.,Saxena, A. K.,Shanker, K.
, p. 443 - 447 (2007/10/02)
Hexahydro-1--3-aryl-2-thioxopyrimidine-4,6-diones (IV) have been prepared and converted into hexahydro-1--3-aryl-5-benzyliden-2-thioxopyrimidine-4,6-diones (V) and hexahydro-1-2-alkyl-4(
