120575-88-4

Upstream product

• 14869-02-4 R-(E)-1-(benzyloxy)pent-3-en-2-ol 
• 75-30-9 2-iodo-propane 
• 79-08-3 bromoacetic acid 

Downstream Products

• 120506-06-1 isopropyl (2S,3R,4E)-6-benzyloxy-2-hydroxy-3-methyl-4-hexenoate 
• 137532-04-8 (2S,3S,4S,5S)-6-benzyloxy-4,5-epoxy-3-methyl-2-(2-tetrahydropyranyloxy)hexan-1-ol 
• 137531-89-6 (2R,3R,4R,5S,8S)-8-(m-benzyloxymethylphenyl)-1,2-epoxy-8-methoxy-3,5-dimethyloctan-4-ol 
• 110314-58-4 (2R,3R,4R,5S,8S)-8--1,2-epoxy-8-methoxy-4-(p-methoxybenzyloxy)-3,5-dimethyloctane 
• 137531-88-5 (2S,3R,4R,5S,8S)-8-(m-benzyloxymethoxyphenyl)-8-methoxy-3,5-dimethyl-2-(2-tetrahydropyranyloxy)octane-1,4-diol 
• 137531-90-9 (2R,3R,8S,9S,10R,11S,14S)-14--1,2-isopropylidenedioxy-14-methoxy-10-(p-methoxybenzyloxy)-6,6-propylenedithio-3,5,5,9,11-pentamethyltetra-decan-8-ol 
• 137531-93-2 (3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-1-[2-((R)-1,1,3-trimethyl-4-oxo-butyl)-[1,3]dithian-2-ylmethyl]-heptyl ester 
• 137531-92-1 (2R,3R,8S,9S,10R,11S,14S)-14--1,2-isopropylidenedioxy-14-methoxy-10-(p-methoxybenzyloxy)-6,6-propylenedithio-3,5,5,9,11-pentamethyltetradecan-8-yl (3R,4R)-4-benzyloxymethoxy-3-(p-methoxybenzyloxy)pentanoate 
• 137531-87-4 (2S,3R,4R,5R,8S)-8-(m-benzyloxymethoxyphenyl)-1-(tert-butyldimethylsiloxy)-5-hydroxymethyl-8-methoxy-3-methyl-2-(2-tetrahydropyranyloxy)octan-4-ol 
• 155433-69-5 Kishi's aldehyde 
• 137532-03-7 (2S,3S,4S,5R)-6-benzyloxy-2-hydroxy-5-iodo-3-methylhexan-4-olide 
• 155433-61-7 (2S,3S)-3-((2S,3S)-3-Benzyloxymethyl-oxiranyl)-2-hydroxy-butyric acid methyl ester 
• 155433-66-2 Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester 
• 155433-67-3 Acetic acid (1R,2S,5S)-1-((1R,2S)-3-acetoxy-2-methanesulfonyloxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester 

Relevant academic research and scientific papers

A Formal Synthesis of Aplysiatoxin: Enantioselective Synthesis of Kishi's Aldehyde

This paper describes the enantioselective synthesis of key fragments (12,18,24, and 35) for the synthesis of aplysiatoxin (1a), a potent cancer promoter, and their convergent assembly to Kishi's aldehyde (2).Since 2 has already been transformed into 1a in

SYNTHESIS OF APLYSIATOXIN: STEREOSELECTIVE SYNTHESIS OF KEY FRAGMENTS

Stereoselective synthesis of key fragments for the synthesis of aplysiatoxin has been achieved.All the stereogenic carbons contained in fragments B-E were elaborated on the basis of Wittig rearrangement and titanium-mediated asymmetric epoxidation.