120590-07-0Relevant academic research and scientific papers
Synthesis of Ethyl 2-propionates and Related Derivatives
Beck, James R.,Babbitt, George E.,Lynch, Michael P.
, p. 1467 - 1470 (2007/10/02)
Alkylation of 1-aryl-1H-1,2,4-triazol-3-ols with ethyl 2-bromopropionate under basic conditions resulted in the formation of 2-propionic acid, ethyl esters.No N-alkylated products were detected.Similar alkylation of 2-oxo-5-phenyl-1,3,4-thiazole and the corresponding 1,3,4-oxadiazole gave only N-alkylated derivatives.With 4-hydroxy-6-phenylpyrimidine and 2-oxo-4-phenylthiazole, both O- and N-alkylation occurred.Structure assignments were based on ir and 13C nmr spectral data.
