4891-69-4

Usage

Uses

Used in Pharmaceutical Industry:
6-Phenyl-4-pyrimidinol is used as an intermediate in the synthesis of pyrazolopyrimidine derivatives, which possess pesticidal and herbicidal properties. These derivatives are integral in the development of new drugs and agrochemicals, contributing to pest control and disease management in agriculture.
Used in Agricultural Chemicals:
In the agricultural sector, 6-Phenyl-4-pyrimidinol serves as a key component in the creation of active ingredients for pesticides and herbicides, enhancing crop protection and yield.
Used in Cosmetics Industry:
6-Phenyl-4-pyrimidinol has been studied for its potential as an active ingredient in sunscreen due to its ability to absorb ultraviolet radiation, offering protection against harmful UV rays and contributing to skin health.
Used in Materials Science:
As an inhibitor of mineralization in bone tissue, 6-Phenyl-4-pyrimidinol is explored for its potential applications in the development of materials that can influence bone health and regeneration.
Used as a Chelating Agent:
6-Phenyl-4-pyrimidinol is utilized for its chelating properties, binding to metal ions to form stable complexes. This characteristic is valuable in various industrial processes where the stabilization of metal ions is required.
While 6-Phenyl-4-pyrimidinol is considered to have low acute oral toxicity, ongoing research is essential to fully understand its health and environmental impacts, ensuring the safe and responsible application of 6-phenyl-4-pyrimidinol in various industries.

InChI:InChI=1/C10H8N2O/c13-10-6-9(11-7-12-10)8-4-2-1-3-5-8/h1-7H,(H,11,12,13)

Upstream product

• 3435-29-8 4-Amino-6-phenylpyrimidine 
• 36822-11-4 6-phenyl-2-thiouracil 
• 86685-13-4 5-formylamino-3-phenylisoxazole 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 77287-34-4 formamide 
• 3435-26-5 4-chloro-6-phenylpyrimidine 
• 64-17-5 ethanol 
• 3438-48-0 4-phenylpyrimidine 
• 4369-55-5 3-phenyl-isoxazol-5-ylamine 
• 1823-99-0 3-amino-3-phenylacrylonitrile 
• 62-53-3 aniline 
• 98-80-6 phenylboronic acid 
• 36822-11-4 4-hydroxy-2-mercapto-6-phenylpyrimidine 
• 7440-44-0 pyrographite 

Downstream Products

• 1358778-49-0 ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyrimidin-1(6H)-yl)butanoate 
• 120590-07-0 2-<(6-phenyl-4-pyrimidinyl)oxy>propionic acid ethyl ester 
• 120590-08-1 2-<6-oxo-4-phenyl-1(6H)-pyrimidinyl>propionic acid ethyl ester 
• 3435-26-5 4-chloro-6-phenylpyrimidine 
• 20551-29-5 4,5-dichloro-6-phenylpyrimidine 
• 3438-48-0 4-phenylpyrimidine 

Relevant academic research and scientific papers

An unprecedented approach to 4,5-disubstituted pyrimidine derivatives by a ZnCl2-catalyzed three-component coupling reaction

We have developed a ZnCI2-catalyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4,5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono- and disubstituted pyrimidine derivatives, using methyl ketone derivatives instead of enamines.

NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

Efficient microwave-assisted synthesis of highly functionalized pyrimidine derivatives

A generally applicable one-pot procedure for the rapid, easy, and diverse asymmetric functionalization of pyrimidines was developed that requires minimum efforts for the purification of the final products. 4-Amino-6-aryl-substituted pyrimidines are prepared in good yields by combined microwave-assisted amination and Suzuki-Miyaura cross-coupling reactions. The acid-mediated amination reaction affords the products as easily separable salts in 30-40 min reaction time.

SYNTHESIS OF SUBSTITUTED 2- AND 4-HYDROXYAMINOPYRIMIDINES

The reaction of 2- and 4-chlorine-containing alkyl(aryl)pyrimidines with hydroxylamine was studied.It was shown that, depending on the amount of hydroxylamine , N,O-dipyrimidinylhydroxyamides or the corresponding 2- and 4-hydroxyaminopyrimidines are formed together with 2- and 4-oxodihydropyrimidines.

The Chichibabin amination of 4-phenyl- and 4-tert-butyl-pyrimidine

During a study on the amination of 4-phenylpyrimidine in potassium amide/liquid ammonia it was found that the extent to which the SN(ANRORC) mechanism operates in the amination largely depends upon whether an ammonium salt is used in quenching the reaction.The composition of the ?-adduct mixture, the structure of the open-chain intermediates, the inhibition of the SN(ANRORC) mechanism and the course of the amination in apolar solvents have been investigated.In addition, it has been found that, in the amination of 4-tert-butylpyrimidine, the SN(ANRORC) mechanism occurs to only a very limited extent.