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120595-72-4

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120595-72-4 Usage

General Description

2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE, also known as cladribine, is a synthetic purine nucleoside analog that is used as an antineoplastic agent. It is believed to exert its cytotoxic effects by inhibiting DNA synthesis and repair, leading to the disruption of cellular function and ultimately cell death. Cladribine is primarily used to treat certain types of leukemia, particularly hairy cell leukemia, and has also been investigated for use in treating other hematological malignancies and autoimmune diseases. Its mechanism of action and ability to target rapidly dividing cells makes it a valuable tool in cancer therapy. Additionally, cladribine has demonstrated immunomodulatory effects and is being explored for its potential in the treatment of multiple sclerosis.

Check Digit Verification of cas no

The CAS Registry Mumber 120595-72-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,9 and 5 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 120595-72:
(8*1)+(7*2)+(6*0)+(5*5)+(4*9)+(3*5)+(2*7)+(1*2)=114
114 % 10 = 4
So 120595-72-4 is a valid CAS Registry Number.

120595-72-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R,3S,5S)-5-(2-amino-6-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

1.2 Other means of identification

Product number -
Other names 2-AMINO-6-CHLOROPURINE-2`-DEOXYRIBOSIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120595-72-4 SDS

120595-72-4Relevant articles and documents

Enzymatic synthesis of 2'-deoxyguanosine with nucleoside deoxyribosyltransferase-II.

Okuyama, Kiyoshi,Shibuya, Susumu,Hamamoto, Tomoki,Noguchi, Toshitada

, p. 989 - 995 (2003)

Nucleoside deoxyribosyltransferase-II (NdRT-II) of Lactobacillus helveticus, which catalyzes the transfer of a glycosyl residue from a donor deoxyribonucleoside to an acceptor base, has a broad specificity for the acceptor bases. Six-substituted purines were found to be substrates as acceptor bases for NdRT-II. Using this property of the enzyme, we established a practical procedure for enzymatic synthesis of 2'-deoxyguanosine (dGuo), consisting of the transglycosylation from thymidine to 6-substituted purine (2-amino-6-chloropurine; ACP) instead of natural guanine and the conversion of 2-amino-6-chloropurine-2'-deoxyriboside (ACPdR) to dGuo with bacterial adenosine deaminase. Through the successive reactions, dGuo was synthesized in high yield.

Chain-terminating and clickable NAD+ analogues for labeling the target proteins of ADP-ribosyltransferases

Wang, Yan,Roesner, Daniel,Grzywa, Magdalena,Marx, Andreas

supporting information, p. 8159 - 8162 (2014/08/18)

ADP-ribosyltransferases (ARTs) use NAD+ as a substrate and play important roles in numerous biological processes, such as the DNA damage response and cell cycle regulation, by transferring multiple ADP-ribose units onto target proteins to form poly(ADP-ribose) (PAR) chains of variable sizes. Efforts to identify direct targets of PARylation, as well as the specific ADP-ribose acceptor sites, must all tackle the complexity of PAR. Herein, we report new NAD+ analogues that are efficiently processed by wild-type ARTs and lead to chain termination owing to a lack of the required hydroxy group, thereby significantly reducing the complexity of the protein modification. Due to the presence of an alkyne group, these NAD+ analogues allow subsequent manipulations by click chemistry for labeling with dyes or affinity markers. This study provides insight into the substrate scope of ARTs and might pave the way for the further developments of chemical tools for investigating PAR metabolism.

Substituted purines and oligonucleotide cross-linking

-

, (2008/06/13)

This invention is directed to novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as "antisense" agents--agents that are capable of specific hybrid

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