1206181-76-1

Basic information

• Product Name: ethyl 4-(1-(3-chlorophenyl)-5-(6-methoxynaphthalen-2-yl)-3-oxopentylamino)benzoate
• CAS NO: 1206181-76-1
• Molecular Weight: 516.037
• Mol File: 1206181-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4-(1-(3-chlorophenyl)-5-(6-methoxynaphthalen-2-yl)-3-oxopentylamino)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(1-(3-chlorophenyl)-5-(6-methoxynaphthalen-2-yl)-3-oxopentylamino)benzoate(1206181-76-1)
• EPA Substance Registry System: ethyl 4-(1-(3-chlorophenyl)-5-(6-methoxynaphthalen-2-yl)-3-oxopentylamino)benzoate(1206181-76-1)

Safety Data

• Hazardous Substances Data: 1206181-76-1(Hazardous Substances Data)

Upstream product

• 42924-53-8 nabumetone 
• 20534-48-9 4-{[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid ethyl ester 
• 587-04-2 m-Chlorobenzaldehyde 
• 94-09-7 p-aminoethylbenzoate 

Relevant articles and documents

Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities

The synthesis of two series of β-amino ketones containing a p-aminobenzoic acid moiety (TM-1 and TM-2) using a modified protocol of the Mannich reaction is reported. The molecular structures of a total of tweenty three new target compounds were characterized by 1H NMR, 13C NMR, ESI-MS and HR-MS. Subsequently, their antidiabetic activities were screened in vitro. The α-glucodase inhibition (α-GI) activity of compound 1e reached a remarkable level of 66.50%. The peroxisome proliferator-activated receptor (PPAR) relative activation activities of six compounds are above 80%, and in particular 2i displays an unprecedentedly high PPAR of 130.91%. The structure-activity relationships of the compounds were established. 2i is also subject to further in-depth investigation.