120621-51-4

Upstream product

• 17094-34-7 ethyl pivaloylacetate 
• 100-52-7 benzaldehyde 
• 75914-61-3 3-(tert-butyl)isoxazol-5 (4H)-one 
• 100-44-7 benzyl chloride 

Downstream Products

• 107576-04-5 (Z)-2-(4-Benzyl-3-tert-butyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-but-2-enedioic acid dimethyl ester 

Relevant academic research and scientific papers

Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles

The Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles 1 at the C5 position has successfully proceeded in the presence of Pd2(dba)3 and P(t-Bu)3·HBF4 catalysts to give the corresponding trisubstituted isoxazoles 3 in good to high yields while suppressing the formation of ketone 4 as a byproduct. The use of bulky phosphine ligand P(t-Bu)3·HBF4 is essential for the current transformation, and the formation of ketone 4, which was a major product in the previous report, was able to be suppressed under the current conditions.

Reaction of Dimethyl Acetylenedicarboxylate with 3,4-Disubstituted Isoxazolin-5-ones. A New Synthesis of of 1,3-Oxazin-6-ones and 2,3-Dihydro-1,3-oxazin-6-ones

Reaction of 3,4-disubstituted isoxazolin-5-ones with dimethyl acetylenedicarboxylate affords 2,2',3,3'-tetrahydro-6,6'-diones.A reaction path is proposed.