1206485-72-4Relevant academic research and scientific papers
Asymmetric synthesis of benzofuryl β-amino alcohols by the transfer hydrogenation of α-functionalized ketones
Tafelska-Kaczmarek, Agnieszka,Krzemiński, Marek P.,?wiklińska, Marta
, p. 3883 - 3897 (2017)
The asymmetric transfer hydrogenation of representative benzofuryl α-sulfonyloxy ketones and N-protected α-amino ketones with an azeotropic mixture of formic acid/triethylamine, catalyzed by RhCl[(R,R)-TsDPEN](C5Me5), afforded the corresponding 1,2-diol monosulfonates and N-substituted β-amino alcohols in high yields and with enantioselectivities up to 99%. Transformation of the reduction products to the chiral benzofuryl β-amino alcohols possessing a primary amine group is also described.
Enantioselective synthesis of (R)-bufuralol via dynamic kinetic resolution in the key step
Johnston, Eric V.,Bogar, Krisztian,Baeckvall, Jan-E.
experimental part, p. 4596 - 4599 (2010/09/30)
(Figure presented) An enantioselective synthesis of (R)-bufuralol via a ruthenium- and enzyme-catalyzed dynamic kinetic resolution (DKR) has been achieved. The synthesis starts from readily available 2-ethylphenol and provides (R)-bufuralol in high ee and a good overall yield of 31%.
Enantioselective Rh-catalyzed transfer hydrogenation of α-sulfonyloxy heteroaryl ketones; asymmetric synthesis of (S)-bufuralol
Kwak, Se Hun,Lee, Do-Min,Lee, Kee-In
experimental part, p. 2639 - 2645 (2010/03/25)
Asymmetric transfer hydrogenation of α-sulfonyloxy heteroaryl ketones mediated by Cp*RhCl[(S,S)-TsDPEN] using an azeotropic mixture of formic acid/triethylamine afforded the corresponding diol-2-monosulfonates in excellent yield with high enantioselectivity. This led to the asymmetric synthesis of (S)-bufuralol.
