1206485-85-9Relevant academic research and scientific papers
New chemo-enzymatic approaches for the synthesis of (R)- and (S)-bufuralol
Nagy, Botond,Dima, Norbert,Paizs, Csaba,Brem, Jürgen,Irimie, Florin Dan,Toa, Monica Ioana
, p. 1316 - 1322 (2014)
Both enantiomers of bufuralol are pharmaceutically important molecules. While the (S)-isomer with a higher β-blocking activity is recommended for hypertension treatment, the (R)-enantiomer can be used as marker of hepatic activity. In this paper two new a
Enantioselective Rh-catalyzed transfer hydrogenation of α-sulfonyloxy heteroaryl ketones; asymmetric synthesis of (S)-bufuralol
Kwak, Se Hun,Lee, Do-Min,Lee, Kee-In
experimental part, p. 2639 - 2645 (2010/03/25)
Asymmetric transfer hydrogenation of α-sulfonyloxy heteroaryl ketones mediated by Cp*RhCl[(S,S)-TsDPEN] using an azeotropic mixture of formic acid/triethylamine afforded the corresponding diol-2-monosulfonates in excellent yield with high enantioselectivity. This led to the asymmetric synthesis of (S)-bufuralol.
