1206524-84-6Relevant articles and documents
Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus
Xu, Feng,Kim, Jungchul,Waldman, Jacob,Wang, Tao,Devine, Paul
, p. 7261 - 7265 (2018/11/23)
An efficient synthesis of grazoprevir is reported. Starting from four readily available building blocks, grazoprevir is prepared in 51% overall yield and >99.9% purity for pharmaceutical use.
METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS
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, (2015/05/05)
The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
METHODS AND INTERMEDIATES FOR THE PREPARATION OF MACROLACTAMS
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, (2015/07/07)
The present invention relates to synthetic processes useful in the preparation of macrolactams that inhibit hepatitis C virus (HCV), specifically macrolactam compounds that inhibit the HCV NS3 protease activity and have application in the treatment of conditions caused by HCV. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.