1224174-07-5

Basic information

• Product Name: (S)-1-chlorohept-6-en-2-ol
• Synonyms: (S)-1-chlorohept-6-en-2-ol
• CAS NO: 1224174-07-5
• Molecular Formula: C7H13ClO
• Molecular Weight: 148.63052
• Mol File: 1224174-07-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-1-chlorohept-6-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-chlorohept-6-en-2-ol(1224174-07-5)
• EPA Substance Registry System: (S)-1-chlorohept-6-en-2-ol(1224174-07-5)

Safety Data

• Hazardous Substances Data: 1224174-07-5(Hazardous Substances Data)

Usage

General Description

(S)-1-chlorohept-6-en-2-ol is a chemical compound with the molecular formula C7H13ClO. It is a chiral compound, meaning it has a non-superimposable mirror image, and is often used in organic synthesis. (S)-1-chlorohept-6-en-2-ol is a colorless liquid with a molecular weight of 148.63 g/mol. It is primarily used as an intermediate in the production of various organic compounds, including pharmaceuticals, agrochemicals, and fragrances. Its structure and properties make it a useful building block for the development of new chemical products. However, it is important to handle this compound with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 5162-44-7 1-bromo-4-butene 
• 67843-74-7 (S)-epichlorohydrin 
• 693-03-8 n-butyl magnesium bromide 
• 7103-09-5 4-but-1-enylmagnesium bromide 

Downstream Products

• 1350619-77-0 (1R,2R)-2-(pent-4-yn-1-yl)cyclopropan-1-ol 
• 1425038-19-2 (S)-3,3-dimethyl-2-(((1R,2R)-2-(pent-4-ynyl)cyclopropoxy)carbonylamino)butanoic acid 
• 1425038-21-6 (S)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-yn-1-yl)cyclopropoxy)carbonyl)amino)butanoic acid tert-butylamine salt 
• 1425038-23-8 methyl (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-18,19-didehydro-1,1a,3,4,5,6,9,10,20,21,22,22a-dodecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3, 6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylate 
• 1206524-84-6 methyl (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxa-diazacyclononadecino[11,12-b]quinoxaline-8-carboxylate 
• 1206524-85-7 (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradeca-hydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid hydrate 
• 1350514-68-9 grazoprevir 

Relevant articles and documents

Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir

A practical and asymmetric synthesis of a functionalized trans-cyclopropoxy building block for the preparation of the HCV NS3/4a protease inhibitor grazoprevir is reported. Intramolecular SN2 displacement-ring closure, followed by a Baeyer-Villiger oxidation, yields the desired trans-cyclopropanol with full control of diastereoselectivity. A terminal alkyne is then effectively installed using LiNH(CH2)2NEt2. Starting from (S)-epichlorohydrin, the cyclopropoxy building block is prepared in 51% overall yield with >99.8% optical purity without isolation of any intermediates.

METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS

The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.