1206531-50-1Relevant articles and documents
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs
Burai, Ritwik,Ramesh, Chinnasamy,Shorty, Marvin,Curpan, Ramona,Bologa, Cristian,Sklar, Larry A.,Oprea, Tudor,Prossnitz, Eric R.,Arterburn, Jeffrey B.
experimental part, p. 2252 - 2259 (2010/07/03)
The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(iii)-catalyzed aza-Diels-Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.