76605-42-0

Basic information

• Product Name: 5-(m-(Trifluoromethyl)benzylidene)hydantoin
• Synonyms: 5-(m-(Trifluoromethyl)benzylidene)hydantoin
• CAS NO: 76605-42-0
• Molecular Formula: C₁₁H₇F₃N₂O₂
• Molecular Weight: 0
• Mol File: 76605-42-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.463g/cm³
• Refractive Index: 1.557
• CAS DataBase Reference: 5-(m-(Trifluoromethyl)benzylidene)hydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(m-(Trifluoromethyl)benzylidene)hydantoin(76605-42-0)
• EPA Substance Registry System: 5-(m-(Trifluoromethyl)benzylidene)hydantoin(76605-42-0)

Safety Data

• Hazardous Substances Data: 76605-42-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H7F3N2O2/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(17)16-10(18)15-8/h1-5H,(H2,15,16,17,18)/b8-5-

Upstream product

• 461-72-3 2,4-imidazolidinedione 
• 454-89-7 3-Trifluoromethylbenzaldehyde 

Downstream Products

• 120658-70-0 2-oxo-m-trifluoromethyl-3-phenylpropionic acid 
• 364782-34-3 cinacalcet hydrochloride 
• 226256-56-0 cinacalcet 
• 76605-52-2 5-(3-Trifluoromethyl-benzyl)-imidazolidine-2,4-dione 

Relevant articles and documents

Preparation method of cinacalcet hydrochloride

The invention relates to a preparation method of cinacalcet hydrochloride. The preparation method comprises the following steps: taking m-trifluoromethyl benzaldehyde, hydantoin and (R)-1-(1-naphthyl)ethylamine as raw materials, performing condensation, hydrolysis, amidation and reduction reaction to prepare cinacalcet, and reacting cinacalcet with hydrochloric acid to prepare cinacalcet hydrochloride. Compared with an existing synthesis method of cinacalcet hydrochloride, the preparation method is short in route and low in raw material cost, the adopted condensing agent is oxalyl chloride and thionyl chloride, which are low in price, the adopted reducing agent is sodium borohydride, which is low in price, a precious metal catalyst (palladium on carbon) is not used, the hydrogenation reaction step is avoided, the requirement for equipment is low, normal-pressure reaction operation can be adopted, and the method is suitable for large-scale industrial production.