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1206604-19-4

5-bromo-2-methylphenylguanidine nitrate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1206604-19-4 Structure

  • Basic information

    1. Product Name: 5-bromo-2-methylphenylguanidine nitrate
    2. Synonyms: 5-bromo-2-methylphenylguanidine nitrate
    3. CAS NO:1206604-19-4
    4. Molecular Formula:
    5. Molecular Weight: 291.104
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1206604-19-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-bromo-2-methylphenylguanidine nitrate(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-bromo-2-methylphenylguanidine nitrate(1206604-19-4)
    11. EPA Substance Registry System: 5-bromo-2-methylphenylguanidine nitrate(1206604-19-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1206604-19-4(Hazardous Substances Data)

1206604-19-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1206604-19-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,6,6,0 and 4 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1206604-19:
(9*1)+(8*2)+(7*0)+(6*6)+(5*6)+(4*0)+(3*4)+(2*1)+(1*9)=114
114 % 10 = 4
So 1206604-19-4 is a valid CAS Registry Number.

1206604-19-4Relevant articles and documents

Synthesis of Imatinib by C-N Coupling Reaction of Primary Amide and Bromo-Substituted Pyrimidine Amine

Wang, Cuiling,Bai, Xiao,Wang, Rui,Zheng, Xudong,Ma, Xiumei,Chen, Huan,Ai, Yun,Bai, Yajun,Liu, Yifeng

, p. 1918 - 1925 (2019)

A new method for imatinib synthesis is described by using the C-N coupling reaction of 4-(4-methylpiperazine-1-methyl)benzamide with N-(5-bromo-2-tolyl)-4-(3-pyridyl)pyrimidin-2-amine to form imatinib. In this synthetic route, the high efficiency and high selectivity of nano-ZnO as a catalyst is key to the mild hydrolysis of 4-(4-methylpiperazine-1-methyl)benzonitrile into the corresponding amide. The total imatinib yield was 51.3%, and the purity was 99.9%. This simple and effective synthetic pathway avoids gene-impurity production (as classified by the FDA Center for Drug Evaluation and Research), and the synthesis is environmentally friendly with a short reaction time.

A PROCESS FOR THE PREPARATION OF IMATINIB

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Page/Page column 6, (2010/04/03)

A process for the preparation of Imatinib according to the invention consists in converting the 2-methyl-5-halogenoaniline of the Formula 2 into the salt of the 2-methyl-5- halogenophenylguanidine of the Formula 3, which is then condensed with the 3-diaIkylamino- ]-(pyridin-3-yI)prop-2-en-l-one of the Formula 4 to yield the N-(2-methyl-5- halogenophenyl)-4-(pyridin-3-yl)-pyrimidin-2-ylamine of the Formula 5, which is then reacted with 4-(4-methylpiperazin-l-ylmethyl)benzamide of the Formula 6, and the obtained Imatinib is optionally converted into its addition salt.

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