1206617-51-7Relevant articles and documents
Total synthesis and cytotoxicity of Leucetta alkaloids
Koswatta, Panduka B.,Kasiri, Sabha,Das, Jayanta K.,Bhan, Arunoday,Lima, Heather M.,Garcia-Barboza, Beatriz,Khatibi, Nicole N.,Yousufuddin, Muhammed,Mandal, Subhrangsu S.,Lovely, Carl J.
, p. 1608 - 1621 (2017/02/26)
The total synthesis of a number of representative natural products isolated from Leucetta and Clathrina sponges containing a polysubstituted 2-aminoimidazole are described. These syntheses take advantage of the site specific metallation reactions of 4,5-diiodoimidazoles resulting in the syntheses of three different classes of Leucetta derived natural products. The cytotoxicities of these natural products, along with several precursors in MCF7 cells were determined through an MTT growth assay. For comparative purposes a series of naphthimidazole-containing family members are included.
Total syntheses of naamidine G and 14-methoxynaamidine G
Koswatta, Panduka B.,Lovely, Carl J.
scheme or table, p. 164 - 166 (2010/03/04)
Simple total syntheses of two Leucetta-derived marine alkaloids have been developed using position-specific halogen-metal exchange of polyhaloimidazoles to introduce the benzyl substituted sidechains. Introduction of the C2 amine group by lithiation and trapping with tosyl azide provides amines on catalytic hydrogenation, which can be converted to naamidine G and 14-methoxynaamidine G using a procedure described in the literature.
