120667-47-2Relevant academic research and scientific papers
Synthesis of 4-phosphono- and of 4-(phosphonomethyl)-dl-phenylalanine, two analogues of O-phosphotyrosine
Bayle-Lacoste, Mireille,Moulines, Jean,Collignon, Noel,Boumekouez, Abdelkader,De Tinguy-Moreaud, Eliane,Neuzil, Eugene
, p. 7793 - 7802 (1990)
:4-Phosphono-DL-phenylalanine 1 was synthetized from 4-bromo-DL-phenylalanine or from 4-(bromomethyl)-bromobenzene ; 4-(phosphonomethyl)-DL-phenylalanine 14 was prepared from methyl p-toluate. The interest of these phosphonic analogues arises from their possible interference in the metabolism of O-phosphotyrosine.
Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists
Bigge,Drummond,Johnson,Malone,Probert Jr.,Marcoux,Coughenour,Brahce
, p. 1580 - 1590 (2007/10/02)
To investigate the preferred spatial relationship of the distal phosphonic acid to the α-amino acid group of the established competitive N-methyl-D-aspartic acid (NMDA) antagonists APH (1) and APV (2), we have prepared a series of ortho-, meta-, and para-
