1206795-80-3

Basic information

• Product Name: (R)-5-hydroxy-4-oxo-5-phenylpentanoic acid
• CAS NO: 1206795-80-3
• Molecular Weight: 208.214
• Mol File: 1206795-80-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-5-hydroxy-4-oxo-5-phenylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-hydroxy-4-oxo-5-phenylpentanoic acid(1206795-80-3)
• EPA Substance Registry System: (R)-5-hydroxy-4-oxo-5-phenylpentanoic acid(1206795-80-3)

Safety Data

• Hazardous Substances Data: 1206795-80-3(Hazardous Substances Data)

Upstream product

• 692-29-5 Succinic semialdehyde 
• 100-52-7 benzaldehyde 
• 328-50-7 α-ketoglutaric acid 

Relevant articles and documents

TCA cycle involved enzymes SucA and Kgd, as well as MenD: Efficient biocatalysts for asymmetric C-C bond formation

Asymmetric mixed carboligation reactions of α-ketoglutarate with different aldehydes were explored with the thiamine diphosphate dependent enzymes SucA from E. coli, Kgd from Mycobacterium tuberculosis, and MenD from E. coli. All three enzymes proved to be efficient biocatalysts to selectively deliver chiral δ-hydroxy-γ-keto acids with moderate to excellent stereoselectivity. The high regioselectivity is due to the preserved role of α-ketoglutarate as acyl donor for these enzyme-catalyzed reactions.