120685-11-2 Usage
Uses
Used in Pharmaceutical Industry:
4'-N-benzoylstaurosporine is used as a broad-spectrum protein kinase inhibitor for its ability to inhibit multiple kinases, including PKA, PKC, S6 Kinase, KDR, Akt, EGFR, VEGFR, PDGFR, c-kit, and FLT-3. This inhibition can lead to disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
Used in Cancer Treatment:
4'-N-benzoylstaurosporine is used as an antitumor agent due to its potent antiproliferative activity in various tumor cell lines. It has been demonstrated to induce apoptosis and shows broad antiproliferative activity, making it a promising candidate for cancer treatment.
Used in Research Applications:
4'-N-benzoylstaurosporine is used as a research tool to study the role of protein kinases in various cellular processes. Its ability to inhibit multiple kinases allows researchers to investigate the specific functions and interactions of these enzymes in the context of cell signaling and other biological pathways.
Biological Activity
Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms ( α , β , γ ), PDFR β , VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
References
1) Odgerel et al. (2008) The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations; Oncogene, 27 3102
2) El Fitori et al. (2007) PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer; Cancer, 110 1457
3) Miyatake, et al. ( 2007) PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.macrophages; Biochem. Biophys. Res. Commun., 360 115
4) Bahlis et.al. (2005) N-Benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells; Leuk. Lymphoma, 46 899
5) Fabbro et al., (2000) PKC-412 – a protein kinase inhibitor with a broad therapeutic potential; Anticancer Drug Des., 15 17
Check Digit Verification of cas no
The CAS Registry Mumber 120685-11-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,6,8 and 5 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 120685-11:
(8*1)+(7*2)+(6*0)+(5*6)+(4*8)+(3*5)+(2*1)+(1*1)=102
102 % 10 = 2
So 120685-11-2 is a valid CAS Registry Number.
