120686-00-2

Basic information

• Product Name: 5-Quinolinecarboxylic acid, 7,8-dihydro-6-hydroxy-2-methoxy-, methyl ester
• CAS NO: 120686-00-2
• Molecular Formula: C12H13NO4
• Molecular Weight: 235.24
• Mol File: 120686-00-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-Quinolinecarboxylic acid, 7,8-dihydro-6-hydroxy-2-methoxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Quinolinecarboxylic acid, 7,8-dihydro-6-hydroxy-2-methoxy-, methyl ester(120686-00-2)
• EPA Substance Registry System: 5-Quinolinecarboxylic acid, 7,8-dihydro-6-hydroxy-2-methoxy-, methyl ester(120686-00-2)

Safety Data

• Hazardous Substances Data: 120686-00-2(Hazardous Substances Data)

Upstream product

• 120685-98-5 1',5',7',8'-tetrahydro-1'-(phenylmethyl)spiro<1,3-dioxolane-2,6'(2'H)-quinolin>-2'-one 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 120685-99-6 7',8'-dihydro-2'-methoxyspiro<1,3-dioxolane-2,6'(5'H)-quinoline> 
• 616-38-6 carbonic acid dimethyl ester 
• 120686-09-1 2-methoxy-6-oxo-5,6,7,8-tetrahydroquinoline 

Downstream Products

• 134757-76-9 6-Hydroxy-2-methoxy-7,8-dihydro-quinoline-5-carboxylic acid (1S,2S,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 

Relevant articles and documents

A process for the synthesis of intermediates in the preparation method of the huperzine-a

The invention discloses a preparation method of an intermediate for synthesizing huperzine A. The preparation method comprises the following steps: substituting 3-bromine-6-methoxy-2-methyl pyridine taken as a raw material with N-bromosuccinimide so as to obtain a substitution product; carrying out a reaction on the substitution product and methyl acetoacetate and then carrying out ring closing reaction under the action of cuprous iodide so as to obtain 2-methoxy-6-hydroxy-7,8-dihydro-5-quinoline carboxylic methyl ester. According to the method provided by the invention, the synthesis reaction cost is low, so that the production cost is effectively lowered; the reaction conditions are moderate, so that the safety of operating personnel is ensured; a refining process is convenient and simple to operate; the intermediate obtained via the reaction is good in quality, high in yield and good in environmental friendliness.

Synthetic chemistery, neurotransmission and second messengers

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