120686-00-2

Upstream product

• 120686-09-1 2-methoxy-6-oxo-5,6,7,8-tetrahydroquinoline 
• 616-38-6 carbonic acid dimethyl ester 
• 120685-99-6 7',8'-dihydro-2'-methoxyspiro<1,3-dioxolane-2,6'(5'H)-quinoline> 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 120685-98-5 1',5',7',8'-tetrahydro-1'-(phenylmethyl)spiro<1,3-dioxolane-2,6'(2'H)-quinolin>-2'-one 

Downstream Products

• 134757-76-9 6-Hydroxy-2-methoxy-7,8-dihydro-quinoline-5-carboxylic acid (1S,2S,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 

Relevant academic research and scientific papers

A process for the synthesis of intermediates in the preparation method of the huperzine-a

The invention discloses a preparation method of an intermediate for synthesizing huperzine A. The preparation method comprises the following steps: substituting 3-bromine-6-methoxy-2-methyl pyridine taken as a raw material with N-bromosuccinimide so as to obtain a substitution product; carrying out a reaction on the substitution product and methyl acetoacetate and then carrying out ring closing reaction under the action of cuprous iodide so as to obtain 2-methoxy-6-hydroxy-7,8-dihydro-5-quinoline carboxylic methyl ester. According to the method provided by the invention, the synthesis reaction cost is low, so that the production cost is effectively lowered; the reaction conditions are moderate, so that the safety of operating personnel is ensured; a refining process is convenient and simple to operate; the intermediate obtained via the reaction is good in quality, high in yield and good in environmental friendliness.

METHOD OF PREPARING HUPERZINE A AND DERIVATIVES THEREOF

The present invention is related to the synthesis of huperzine A. The synthesis includes a variety of process steps that increase productivity, reduce safety concerns, and allow for increasing production of compounds of desired optical isomer. The inventive methods may encompass a single improved reaction step that may be incorporated into a known reaction process for synthesizing huperzine A or a derivative thereof to improve the overall reaction. The inventive methods also encompass complete synthesis methods for preparing huperzine A or a derivative thereof.