1206876-13-2Relevant academic research and scientific papers
Substituted tetrahydro-β-carbolines as potential agents for the treatment of human papillomavirus infection
Miller, John F.,Turner, Elizabeth M.,Sherrill, Ronald G.,Gudmundsson, Kristjan,Spaltenstein, Andrew,Sethna, Phiroze,Brown, Kevin W.,Harvey, Robert,Romines, Karen R.,Golden, Pamela
experimental part, p. 256 - 259 (2010/04/05)
The identification and optimization of a series of substituted tetrahydro-β-carbolines with potent activity against human papillomavirus is described. Structure-activity studies focused on the substitution pattern and chirality of the β-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range.
