1206978-11-1

Basic information

• Product Name: 2-BroMo-3-(trifluoroMethoxy)pyridine
• Synonyms: 2-BroMo-3-(trifluoroMethoxy)pyridine;2-Bromo-3-(trifluoromethoxy)
• CAS NO: 1206978-11-1
• Molecular Formula: C6H3BrF3NO
• Molecular Weight: 241.9933296
• Mol File: 1206978-11-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BroMo-3-(trifluoroMethoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-3-(trifluoroMethoxy)pyridine(1206978-11-1)
• EPA Substance Registry System: 2-BroMo-3-(trifluoroMethoxy)pyridine(1206978-11-1)

Safety Data

• RIDADR: UN2810
• Hazardous Substances Data: 1206978-11-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Bromo-3-(trifluoromethoxy)pyridine is used as a building block for synthesizing potential drug candidates. Its high lipophilicity and versatile reactivity make it a valuable component in the development of biologically active compounds with improved absorption and distribution properties.
Used in Agrochemical Research:
2-Bromo-3-(trifluoromethoxy)pyridine is used as a building block for synthesizing potential crop protection products. Its reactivity and halogenating properties enable the development of new agrochemicals with enhanced efficacy and selectivity.

Upstream product

• 1258190-90-7 2-bromo-3-(trichloromethoxy)pyridine 
• 39856-58-1 3-amino-2-bromopyridine 
• 1006904-72-8 silver(I) trifluoromethoxide 
• 1206980-39-3 2-chloro-3-(trifluoromethoxy)pyridine 

Downstream Products

• 1221171-81-8 3-(trifluoromethoxy)pyridine-2-carboxylic acid 
• 1206977-79-8 1-[3-(trifluoromethoxy)pyridin-2-yl]methanamine 

Relevant articles and documents

Silver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds.

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.

METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES

The present invention pertains to a process for the preparation of functionalized trihalomethoxypyridines of formula (I) comprising reacting hydroxypyridines with thiophosgene in the presence of a base; reacting the obtained chlorothionoformiates with elemental chlorine and finally converting trichloromethoxy pyridines to trihalomethoxy pyridines using a fluoride source.