1221171-81-8

Basic information

• Product Name: 3-(trifluoroMethoxy)picolinic acid
• Synonyms: 3-(trifluoroMethoxy)picolinic acid
• CAS NO: 1221171-81-8
• Molecular Formula: C7H4F3NO3
• Molecular Weight: 207.1067696
• Mol File: 1221171-81-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(trifluoroMethoxy)picolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(trifluoroMethoxy)picolinic acid(1221171-81-8)
• EPA Substance Registry System: 3-(trifluoroMethoxy)picolinic acid(1221171-81-8)

Safety Data

• Hazardous Substances Data: 1221171-81-8(Hazardous Substances Data)

Usage

General Description

3-(trifluoroMethoxy)picolinic acid is a chemical compound with the molecular formula C7H5F3NO3. It is a derivative of pyridine and contains a picolinic acid group with a trifluoromethoxy substituent. 3-(trifluoroMethoxy)picolinic acid is commonly used in pharmaceutical and agrochemical research as a building block for the synthesis of various biologically active compounds. It has been studied for its potential anti-inflammatory and antitumor properties, and its trifluoromethoxy group makes it a valuable tool for the development of new drugs. Additionally, 3-(trifluoroMethoxy)picolinic acid has shown potential as a ligand for metal complexes and has been used in coordination chemistry studies. Overall, this compound has diverse applications in the fields of medicinal chemistry and chemical biology.

Upstream product

• 1221171-83-0 6-chloro-3-(trifluoromethoxy)pyridine-2-carboxylic acid 
• 124-38-9 carbon dioxide 
• 1206978-11-1 2-bromo-3-(trifluoromethoxy)pyridine 

Relevant articles and documents

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.