1207110-53-9Relevant academic research and scientific papers
Synthesis, chemical reactivity as michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents(1)
Zheng, Suqing,Santosh Laxmi,David, Emilie,Dinkova-Kostova, Albena T.,Shiavoni, Katherine H.,Ren, Yanqing,Zheng, Ying,Trevino, Isaac,Bumeister, Ronald,Ojima, Iwao,Wigley, W. Christian,Bliska, James B.,Mierke, Dale F.,Honda, Tadashi
, p. 4837 - 4846 (2012/07/03)
Novel monocyclic cyanoenones examined to date display unique features regarding chemical reactivity as Michael acceptors and biological potency. Remarkably, in some biological assays, the simple structure is more potent than pentacyclic triterpenoids (e.g
MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF
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Page/Page column 110-111, (2010/04/03)
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
