1207366-48-0

Basic information

• Product Name: C₂₆H₂₆N₈O₂
• CAS NO: 1207366-48-0
• Molecular Weight: 482.545
• Mol File: 1207366-48-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₆N₈O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₆N₈O₂(1207366-48-0)
• EPA Substance Registry System: C₂₆H₂₆N₈O₂(1207366-48-0)

Safety Data

• Hazardous Substances Data: 1207366-48-0(Hazardous Substances Data)

Upstream product

• 1207370-33-9 4-(2-(4-nitrophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)morpholine 
• 1415797-56-6 4-(2-(4-nitrophenyl)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)morpholine 
• 916420-27-4 2,4-dichloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester 
• 1415797-55-5 tert-butyl 4-morpholino-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate 
• 171364-83-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene 
• 1415797-57-7 6-(benzyloxy)-N-(4-(4-morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)pyridin-2-amine 
• 1207358-78-8 4-(4-morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline 
• 117068-71-0 2-(benzyloxy)-6-bromopyridine 
• 626-05-1 2,6-Dibromopyridine 
• 1207370-38-4 tert-butyl 2-chloro-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate 

Relevant articles and documents

Discovery and biological profiling of potent and selective mTOR inhibitor GDC-0349

Aberrant activation of the PI3K-Akt-mTOR signaling pathway has been observed in human tumors and tumor cell lines, indicating that these protein kinases may be attractive therapeutic targets for treating cancer. Optimization of advanced lead 1 culminated in the discovery of clinical development candidate 8h, GDC-0349, a potent and selective ATP-competitive inhibitor of mTOR. GDC-0349 demonstrates pathway modulation and dose-dependent efficacy in mouse xenograft cancer models.