1207452-03-6

Basic information

• Product Name: C₄₀H₅₉N₅O₁₀S₂Si₂
• CAS NO: 1207452-03-6
• Molecular Weight: 890.239
• Mol File: 1207452-03-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₀H₅₉N₅O₁₀S₂Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₀H₅₉N₅O₁₀S₂Si₂(1207452-03-6)
• EPA Substance Registry System: C₄₀H₅₉N₅O₁₀S₂Si₂(1207452-03-6)

Safety Data

• Hazardous Substances Data: 1207452-03-6(Hazardous Substances Data)

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 69304-44-5 3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine 

Relevant articles and documents

Facile and efficient approach for the synthesis of N2-dimethylaminomethylene-2′-O-methylguanosine

A convenient method for the synthesis of N2-dimethylaminomethylene-2′-O-methylguanosine (1), which is a useful intermediate for oligonucleotide construction, was developed. We chose the di-tert-butylsilyl group and the triisopropylbenzenesulfonyl group as sugar and base protecting groups, respectively. These protecting groups were stable during the 2′-O-methylation step with MeI and NaH. Our six-step synthesis of 1 is easy to perform using commercially available reagents, and requires only three chromatographic purifications. Compound 1 was obtained in 56% yield from guanosine.