69304-44-5

Basic information

• Product Name: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine
• Synonyms: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disoloxanediyl)guanosine;3',5'-TIPS-guanosine;3',5'-O-(1,1,3,3-TETRAISOPROPYLDISILOXAN-1,3-DIYL)-GUANOSINE;3',5'-(TETRAISOPROPYL-DISILOXANE-1,3-DIYL)-GUANOSINE;3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine
• CAS NO: 69304-44-5
• Molecular Formula: C₂₂H₃₉N₅O₆Si₂
• Molecular Weight: 525.75
• Product Categories: Nucleosides
• Mol File: 69304-44-5.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine(69304-44-5)
• EPA Substance Registry System: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine(69304-44-5)

Safety Data

• Hazardous Substances Data: 69304-44-5(Hazardous Substances Data)

Usage

Uses

3'',5''-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine (CAS# 69304-44-5) is a silicon-containing hindered nucleoside, used as antiflaviviridae agents against BVDV, YFV, DENV, and WNV viruses in cell-based assays.

Upstream product

• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 118-00-3 guanosine 
• 87865-78-9 3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-N₂-isobutyrylguanosine 
• 18043-71-5 1,1,3,3-tetraisopropyldisiloxane 
• 18173-84-7 diisopropylsilanol 
• 118-00-3 G 

Downstream Products

• 188658-54-0 6-O-(tert-Butyldiphenylsilyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 183737-04-4 N₂-dimethylaminomethylene-2'-O-methylguanosine 
• 206552-86-5 2'-O-propargyl guanosine 
• 197151-05-6 6-O-(2-Nitrophenyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 197151-06-7 2'-O-Methyl-6-O-(2-nitrophenyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 197151-07-8 2'-O-Allyl-6-O-(2-nitrophenyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 197151-08-9 6-O-(2-Nitrophenyl)-2'-O-propargyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 1053577-35-7 6-(2-Nitro-phenoxy)-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-trimethylsilanyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-ylamine 
• 197151-09-0 2'-O-Cyanomethyl-6-O-(2-nitrophenyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 197151-10-3 2'-O-(Ethoxycarbonyl)methyl-6-O-(2-nitrophenyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 197151-11-4 2-N-Isobutyryl-2'-O-methyl-6-O-(2-nitrophenyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 197151-23-8 6-(tert-Butyl-diphenyl-silanyloxy)-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-prop-2-ynyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-ylamine 
• 197151-12-5 2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 197151-24-9 {(2R,3R,3aR,9aR)-2-[2-Amino-6-(tert-butyl-diphenyl-silanyloxy)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy}-acetonitrile 

Relevant articles and documents

Partial Synthesis of Leader Sequence of Phage f1 Coat Protein mRNA

Tetra to undecaribonucleotides of the leader sequence in messenger RNA(mRNA) of f1 coat protein were synthesized on a polystyrene solid support through simple phosphotriester approach.

SPIROTHIETANE NUCLEOSIDES

The present invention relates to 2'-spirothietane nucleosides, and the phosphates and the prodrugs thereof, and the pharmaceutically acceptable salts and solvates thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Flaviviridae family and/or to the alphavirus genus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Flaviviridae family and/or to the alphavirus genus. The invention also relates to processes for the preparation of the compounds.

Molybdopterin biosynthesis: Trapping of intermediates for the MoaA-catalyzed reaction using 2′-deoxyGTP and 2′-chloroGTP as substrate analogues.

MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a complex rearrangement of guanosine-5'-triphosphate (GTP) in the first step of molybdopterin biosynthesis. In this paper, we provide additional characterization of the MoaA reaction product, describe the use of 2′-chloroGTP to trap the GTP C3′ radical, generated by hydrogen atom transfer to the 5′-deoxyadenosyl radical, and the use of 2′-deoxyGTP to block a late step in the reaction sequence. These probes, coupled with the previously reported trapping of an intermediate in which C3′ of the ribose is linked to C8 of the purine, allow us to propose a plausible mechanism for the MoaA-catalyzed reaction.