69304-44-5Relevant articles and documents
Partial Synthesis of Leader Sequence of Phage f1 Coat Protein mRNA
Hirao, Ichiro,Ishikawa, Masahide,Miura, Kin-ichiro
, p. 1929 - 1932 (1986)
Tetra to undecaribonucleotides of the leader sequence in messenger RNA(mRNA) of f1 coat protein were synthesized on a polystyrene solid support through simple phosphotriester approach.
MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE IN TAUOPATHIES
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Paragraph 0239, (2019/10/04)
Oligonucleotides comprising modifications at the 2' and/or 3' positions(s) along with methods of 5 making and use against Alzheimer disease and other tauopathies are disclosed.
SPIROTHIETANE NUCLEOSIDES
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Page/Page column 66, (2019/03/17)
The present invention relates to 2'-spirothietane nucleosides, and the phosphates and the prodrugs thereof, and the pharmaceutically acceptable salts and solvates thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Flaviviridae family and/or to the alphavirus genus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Flaviviridae family and/or to the alphavirus genus. The invention also relates to processes for the preparation of the compounds.
MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE
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Paragraph 0227, (2018/04/12)
Modified oligonucleotides comprising modifications at the 2' and/or 3' positions(s) along with methods of making and use, e.g., against HBV are disclosed.
Molybdopterin biosynthesis: Trapping of intermediates for the MoaA-catalyzed reaction using 2′-deoxyGTP and 2′-chloroGTP as substrate analogues.
Mehta, Angad P.,Abdelwahed, Sameh H.,Xu, Hui,Begley, Tadhg P.
supporting information, p. 10609 - 10614 (2014/08/18)
MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a complex rearrangement of guanosine-5'-triphosphate (GTP) in the first step of molybdopterin biosynthesis. In this paper, we provide additional characterization of the MoaA reaction product, describe the use of 2′-chloroGTP to trap the GTP C3′ radical, generated by hydrogen atom transfer to the 5′-deoxyadenosyl radical, and the use of 2′-deoxyGTP to block a late step in the reaction sequence. These probes, coupled with the previously reported trapping of an intermediate in which C3′ of the ribose is linked to C8 of the purine, allow us to propose a plausible mechanism for the MoaA-catalyzed reaction.
A new protocol for selective cleavage of acyl protecting groups in 2′-O-modified 3′,5′-O -(Tetraisopropyldisiloxane-1,3-diyl) ribonucleosides
Drenichev,Kulikova,Bobkov,Tararov,Mikhailov
scheme or table, p. 3827 - 3834 (2011/01/12)
The stability of tetraisopropyldisiloxane-1,3-diyl (TIPDS) protection in nucleosides in ammonia/amine solutions in methanol and ethanol was studied. In ammonia-methanol at ambient temperature significant partial cleavage of TIPDS was observed. When ethano
Preparation of zwitterionic ribonucleoside phosphoramidites for solid-phase siRNA synthesis
Smicius, Romualdas,Engels, Joachim W.
, p. 4994 - 5002 (2008/12/20)
(Chemical Equation Presented) RNA oligomers, carrying 2′-O-modified nucleosides, proved to be extremely useful in different antisense strategies, including RNAi. The 2′-O-alkyl modification, carrying an amino functionality, deserves special attention due
Preparation of deoxynucleosides
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Page column 14, (2008/06/13)
Methods for preparing deoxynucleosides from their corresponding ribonucleosides by forming 3-tert-butylphenoxythiocarbonylderivatives of the ribonucleosides and subsequently effecting radical deoxygenation reactions at the carbon atoms to be deoxygenated.
Low-temperature photosensitized oxidation of a guanosine derivative and formation of an imidazole ring-opened product
Sheu, Chimin,Kang, Ping,Khan, Saeed,Foote, Christopher S.
, p. 3905 - 3913 (2007/10/03)
An organic-soluble guanosine derivative, 2′,3′,5′-O-(tert-butyldimethylsilyl)guanosine (1), was prepared and its photosensitized oxidation was carried out in several solvents at various temperatures. Singlet oxygen is the reactive oxidizing agent responsi
Synthesis of 2'-iodo- and 2'-bromo-ATP and GTP analogues as potential phasing tools for X-ray crystallography
Gruen, Mathias,Becker, Christian,Beste, Andrea,Siethoff, Christoph,Scheidig, Axel J.,Goody, Roger S.
, p. 137 - 151 (2007/10/03)
Ara-adenosine (adenine 9-β-D-arabinofuranoside) and ara-guanosine (guanine 9-β-D-arabinofuranoside) are converted into 2' halogenated ATP and GTP analogues by triflation and subsequent inversion of configuration at C- 2'. For the commercially unavailable ara-guanosine a short synthesis starting from guanosine is presented. The nucleotide analogues could serve for the preparation of heavy atom derivatives of ATP- and GTP-binding proteins useful for protein crystal structure determination by MIR/MAD phasing.