1207460-27-2

Upstream product

• 74-89-5 methylamine 
• 1207460-26-1 tert-butyl ((E)-(6-{2-chloro-[4-(4'-fluorophenyl)-6-isopropyl]-pyrimidin-5-yl}-vinyl)-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetate 

Downstream Products

• 289042-12-2 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester 
• 355806-00-7 rosuvastatin tert-butyl ester 

Relevant academic research and scientific papers

Ruishufatatinggan and wherein the intermediate preparation method

The invention relates to preparation methods for rosuvastatin calcium and intermediates thereof. Specifically, the invention discloses intermediate compounds for preparing rosuvastatin calcium and a preparation method of the intermediate compounds, and the intermediates are the compounds shown as formula V and formula VI. The invention also discloses a preparation method of rosuvastatin calcium or salts thereof, and the preparation method is based on the two intermediate compounds and the preparation method thereof. The preparation is simple and safe in operation, low in production cost and applicable to industrialized production.

A PROCESS FOR PREPARING HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES

The present invention relates to an improved process for synthesizing calcium salt of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoic acid (Rosuvastatin Calcium) in high purity.