1207533-91-2

Basic information

• Product Name: (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride
• Synonyms: (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride
• CAS NO: 1207533-91-2
• Molecular Weight: 391.864
• Mol File: 1207533-91-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride(1207533-91-2)
• EPA Substance Registry System: (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride(1207533-91-2)

Safety Data

• Hazardous Substances Data: 1207533-91-2(Hazardous Substances Data)

Upstream product

• 779-89-5 3-(trifluoromethyl)cinnamic acid 
• 3886-70-2 (R)-1-(1-Naphthyl)ethylamine 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 1279582-34-1 3-chloro-N-[(1R)-1-(naphthalen-1-yl)ethyl ]prop-2-en-1-amine 
• 64189-17-9 3-<3-(trifluoromethyl)phenyl>prop-2-en-1-ol 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 
• 154309-48-5 1-<3-(trifluoromethyl)phenyl>prop-2-en-1-ol 
• 1273319-40-6 1-(1-chloroprop-2-en-1-yl)-3-(trifluoromethyl)benzene 
• 41412-73-1 1-[3-chloroprop-1-en-1-yl]-3-(trifluoromethyl)benzene 
• 454-89-7 3-Trifluoromethylbenzaldehyde 

Downstream Products

• 1204313-91-6 (R)-tert-butyl (1-(naphthalen-1-yl)ethyl)(3-(3-(trifluoromethyl)phenyl)propyl)carbamate 
• 1207534-31-3 C₂₇H₂₈F₃NO₂ 
• 364782-34-3 cinacalcet hydrochloride 
• 226256-56-0 cinacalcet 
• 1273319-38-2 N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate 

Relevant articles and documents

A novel method for the large scale synthesis of cinacalcet hydrochloride using iron catalyzed C-C coupling

A novel synthetic route for commercial preparation of cinacalcet hydrochloride (1), a calcimimetic agent and calcium-sensing receptor antagonist, is described. Our synthetic approach involves the preparation of cinacalcet using C-C bond formation catalyzed by iron acetylacetonate/NMP complex with aryl Grignard reagent benzotrifluoride magnesium bromide (8) and alkenyl halide N-chloropropene naphthylethylamine (6).

PROCESSES FOR THE PREPARATION OF CINACALCET

The present invention provides processes and intermediates for preparing cinacalcet base and pharmaceutically acceptable salts thereof.

UNSATURATED CINACALCET SALTS AND PROCESSES FOR PREPARING CINACALCET HYDROCHLORIDE

Disclosed herein are convenient, industrially advantageous and environmentally friendly processes for the preparation of cinacalcet hydrochloride. Disclosed also herein are novel hydrochloride, oxalate and di-p-toluoyl-L-(+)-tartrate salts of (R)-a-methyl-N-[3-[3- (trifluoromethyl)phenyl]propylene]-l -naphthalenemethaneamine (unsaturated cinacalcet), solid state forms of the salts, and a process for their preparation thereof.