1207538-22-4

Basic information

• Product Name: α(1,2),α(1,6)-pseudomannotriose
• Synonyms: α(1,2),α(1,6)-pseudomannotriose
• CAS NO: 1207538-22-4
• Molecular Weight: 599.587
• Mol File: 1207538-22-4.mol

Chemical Properties

• CAS DataBase Reference: α(1,2),α(1,6)-pseudomannotriose(CAS DataBase Reference)
• NIST Chemistry Reference: α(1,2),α(1,6)-pseudomannotriose(1207538-22-4)
• EPA Substance Registry System: α(1,2),α(1,6)-pseudomannotriose(1207538-22-4)

Safety Data

• Hazardous Substances Data: 1207538-22-4(Hazardous Substances Data)

Upstream product

• 1207538-21-3 C₅₈H₆₁N₃O₂₃ 
• 845870-02-2 C₁₀H₁₄O₅ 
• 1207538-18-8 (2-azidoethyl)-2,3,4-tri-O-acetyl-α-D-mannopyranoside 
• 1207538-19-9 C₂₄H₃₅N₃O₁₄ 
• 1207538-28-0 C₂₀H₃₅N₃O₉Si 
• 155196-97-7 2-azidoethyl α-D-mannopyranoside 
• 140428-83-7 2-azidoethyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 1207538-17-7 C₂₄H₃₉N₃O₁₆ 

Downstream Products

• 1207538-26-8 SARA 133 

Relevant articles and documents

Inhibitors of microbial infections

The present invention finds application in the field of medicine and, in particular, it relates to new compounds for the treatment and/or prevention of HIV; Ebola, Dengue, Hepatitis C, SARS or tuberculosis infections.

INHIBITORS OF MICROBIAL INFECTIONS

The present invention finds application in the field of medicine and, in particular, it relates to new compounds for the treatment and/or prevention of HIV; Ebola, Dengue, Hepatitis C, SARS or tuberculosis infections.

Inhibition of DC-SIGN-mediated HIV infection by a linear trimannoside mimic in a tetravalent presentation

HIV infection is pandemic in humans and is responsible for millions of deaths every year. The discovery of new cellular targets that can be used to prevent the infection process represents a new opportunity for developing more effective antiviral drugs. In this context, dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN), a lectin expressed at the surface of immature dendritic cells and involved in the initial stages of HIV infection, is a promising therapeutic target. Herein we show the ability of a new tetravalent dendron containing four copies of a linear trimannoside mimic to inhibit the trans HIV infection process of CD4 T lymphocytes at low micromolar range. This compound presents a high solubility in physiological media, a neglectable cytotoxicity, and a long-lasting effect and is based on carbohydrate-mimic units. Notably, the HIV antiviral activity is independent of viral tropism (X4 or R5). The formulation of this compound as a gel could allow its use as topical microbicide.