1207729-67-6

Basic information

• Product Name: (S)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine
• Synonyms: (S)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine
• CAS NO: 1207729-67-6
• Molecular Weight: 330.289
• Mol File: 1207729-67-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine(1207729-67-6)
• EPA Substance Registry System: (S)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-bromophenyl)-pyrrolidine(1207729-67-6)

Safety Data

• Hazardous Substances Data: 1207729-67-6(Hazardous Substances Data)

Upstream product

• 1218989-23-1 (S,E)-N-(4-chloro-1-(4-bromophenyl)butylidene)-2-methylpropane-2-sulfinamide 
• 4559-96-0 1-(4-bromophenyl)-4-chlorobutan-1-one 
• 1330770-67-6 C₁₄H₂₁BrClNOS 

Downstream Products

• 1189152-82-6 (S)-2-(4-bromophenyl)-pyrrolidine 

Relevant articles and documents

PROCESS FOR SYNTHESIS OF 2-SUBSTITUTED PYRROLIDINES AND PIPERADINES

The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

Asymmetric synthesis of 2-substituted pyrrolidines by addition of Grignard reagents to γ-chlorinated N-tert-butanesulfinyl imine

A highly diastereoselective addition of various Grignard reagents to chiral γ-chlorinated N-tert-butanesulfinyl imine resulting in the formation of 2-substituted pyrrolidines is reported. This method is general and also efficient for the preparation of both enantiomers of 2-aryl, 2-alkyl and 2-vinyl substituted pyrrolidines in high yields.