4559-96-0

Basic information

• Product Name: 4'-BROMO-4-CHLOROBUTYROPHENONE
• Synonyms: P-BROMO-G-CHLOROBUTYROPHENONE;4'-BROMO-4-CHLOROBUTYROPHENONE 98%;4'-Bromo-4-chlorobutyrophenone,99%;4'-Bromo-γ-chlorobutyrophenone;γ-Chloro-4'-bromobutyrophenone;1-(4-BROMOPHENYL)-4-CHLORO-1-BUTANONE;1-(4-BROMOPHENYL)-4-CHLORO-1-OXOBUTANE;4-BROMO-GAMMA-CHLOROBUTYROPHENONE
• CAS NO: 4559-96-0
• Molecular Formula: C₁₀H₁₀BrClO
• Molecular Weight: 261.54
• EINECS: 224-930-3
• Mol File: 4559-96-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 35.5-38 °C(lit.)
• Boiling Point: 352.8°Cat760mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.4780 (rough estimate)
• Refractive Index: 1.5963 (estimate)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 4'-BROMO-4-CHLOROBUTYROPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-4-CHLOROBUTYROPHENONE(4559-96-0)
• EPA Substance Registry System: 4'-BROMO-4-CHLOROBUTYROPHENONE(4559-96-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 4559-96-0(Hazardous Substances Data)

Usage

Chemical Properties

cream low melting powder

Uses

4'-Bromo-4-chlorobutyrophenone is used as a pharmaceutical & syntheses material intermediates.

Upstream product

• 19936-14-2 1-(4-bromophenyl)cyclobutan-1-ol 
• 589-87-7 1,4-bromoiodobenzene 
• 108-86-1 bromobenzene 
• 4635-59-0 4-Chlorobutanoyl chloride 

Downstream Products

• 71526-81-3 8a-(4-bromo-phenyl)-hexahydro-pyrrolo[2,1-b][1,3]oxazine 
• 149490-78-8 1-(4-bromophenyl)-4-(1H-imidazol-1-yl)-1-butanone 
• 112933-70-7 (S)-1-(4-Bromo-phenyl)-1-cyclopropyl-2-methanesulfinyl-ethanol 
• 130570-12-6 3-p-Methylphenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride 
• 130570-17-1 3-p-Methoxyphenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride 
• 130570-07-9 3-p-Fluorophenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride 
• 130570-02-4 3-p-Chlorophenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride 
• 6952-89-2 (4-bromophenyl)(cyclopropyl)methanone 
• 84702-76-1 4-azido-4'-bromobutylphenone 
• 168907-66-2 4'-bromo-4-iodobutyrophenone 
• 649569-54-0 thioacetic acid S-[4-(4-bromo-phenyl)-4-oxo-butyl] ester 
• 149490-99-3 [(2S,5R)-2-(4-Bromo-phenyl)-2-(3-imidazol-1-yl-propyl)-[1,3]oxathiolan-5-yl]-methanol 
• 149490-99-3 [(2S,5S)-2-(4-Bromo-phenyl)-2-(3-imidazol-1-yl-propyl)-[1,3]oxathiolan-5-yl]-methanol 
• 1310948-43-6 3-[2-(4-Bromophenyl)-1,3-dioxolan-2-yl]-N,N-diethylpropan-1-amine 

Relevant articles and documents

Preparation method of fexofenadine

The invention provides a preparation method of fexofenadine, which comprises the following steps: by using bromobenzene as a raw material, carrying out Friedel-Crafts acylation reaction to obtain 4'-bromo-4-chlorophenone ; enabling 4'-bromo-4-chlorobutanone and 1-methoxy-1-(trimethylsiloxy)-2-methyl-1-propene to subjected to coupling reaction to obtain 2-[4-(4 -chloro-1-butyryl)phenyl]-2-methyl methyl propionate; and sequentially carrying out N-alkylation, carbonyl reduction and alkaline hydrolysis on 2-[4-(4 -chloro-1-butyryl)phenyl]-2-methylpropanoate to obtain fexofenadine. The method has the advantages of cheap and easily available raw materials, easiness in operation, high yield, low cost, no meta-isomer, suitability for industrial production and the like.

Regioselective Synthesis of Carbonyl-Containing Alkyl Chlorides via Silver-Catalyzed Ring-Opening Chlorination of Cycloalkanols

A novel and regioselective approach to carbonyl-containing alkyl chlorides via silver-catalyzed ring-opening chlorination of cycloalkanols is reported. Concurrent C(sp3)-C(sp3) bond cleavage and C(sp3)-Cl bond formation efficiently occur with good yields under mild conditions, and the chlorinated products are readily transformed into other useful synthetic intermediates and drugs. The reaction features complete regioselectivity, high efficiency, and excellent practicality. (Chemical Equation Presented).

The synthesis of ω-(2-aryl-1,3-dioxolan-2-yl)alkyl purine derivatives and their activity towards HIV reverse transcriptase

Novel derivatives of 6-substituted purines were synthesized by alkylation of 6-substituted purines with various 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. Their inhibitory properties toward HIV reverse transcriptase were studied. The structure-activity relationship within the synthesized compounds was found.