1207746-99-3Relevant academic research and scientific papers
Discovery of MK-4409, a novel oxazole FAAH inhibitor for the treatment of inflammatory and neuropathic pain
Chobanian, Harry R.,Guo, Yan,Liu, Ping,Chioda, Marc D.,Fung, Selena,Lanza, Thomas J.,Chang, Linda,Bakshi, Raman K.,Dellureficio, James P.,Hong, Qingmei,McLaughlin, Mark,Belyk, Kevin M.,Krska, Shane W.,Makarewicz, Amanda K.,Martel, Elliot J.,Leone, Joseph F.,Frey, Lisa,Karanam, Bindhu,Madeira, Maria,Alvaro, Raul,Shuman, Joyce,Salituro, Gino,Terebetski, Jenna L.,Jochnowitz, Nina,Mistry, Shruti,McGowan, Erin,Hajdu, Richard,Rosenbach, Mark,Abbadie, Catherine,Alexander, Jessica P.,Shiao, Lin-Lin,Sullivan, Kathleen M.,Nargund, Ravi P.,Wyvratt, Matthew J.,Lin, Linus S.,Devita, Robert J.
supporting information, p. 717 - 721 (2014/07/07)
We report herein the identification of MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Starting from a high throughput screening (HTS) hit, medicinal chemistry efforts focused on optimizing of FAAH inhibition in vitro potency,
OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH
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Page/Page column 13; 14, (2011/02/18)
The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.
OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH
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Page/Page column 33, (2010/04/03)
The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
